PXD040251
PXD040251 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons |
| Description | Progranulin (PGRN) is a lysosomal protein involved in various neurodegenerative diseases. Over 70 mutations discovered in the GRN gene all result in reduced expression of PGRN protein. However, the detailed molecular function of PGRN within lysosomes and the impact of PGRN deficiency on lysosomal biology remain unclear. Here we leveraged multi-faceted proteomic techniques to comprehensively characterize how PGRN deficiency changes the molecular and functional landscape of neuronal lysosomes. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-02-10 |
| AnnouncementXML | Submission_2025-02-10_07:17:42.686.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Ling Hao |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Oxidation; Acetyl; Carbamidomethyl |
| Instrument | Orbitrap Fusion Lumos; instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-02-19 09:56:46 | ID requested | |
| ⏵ 1 | 2025-02-10 07:17:43 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Progranulin, Dynamic SILAC, lysosome, neurons, autophagy, frontotemporal dementia , proximity labeling |
Contact List
| Ling Hao | |
|---|---|
| contact affiliation | George Washington University |
| contact email | linghao@gwu.edu |
| lab head | |
| Ling Hao | |
| contact affiliation | University of Maryland |
| contact email | haolab.19@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v05/MSV000091323/ |
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