PXD040239

PXD040239 is an original dataset announced via ProteomeXchange.

Title	A snapshot of Bothrops jararaca snake venom gland subcellular proteome
Description	The synthesis of snake venom proteins is subjected to finely regulated processes in the specialized secretory epithelium within the venom gland. Such processes occur within a defined time frame in the cell and at specific cellular locations. Thus, the determination of subcellular proteomes allows the characterization of protein groups for which the site may be relevant to their biological roles, thereby allowing the deconvolution of complex biological circuits into functional information. In the case of snake venom glands, subcellular proteome analysis could help understand the molecular basis of venom variability. Consequently, knowing the functional implications of such phenotypic plasticity could prove relevant in envenoming treatment and biological research. In this regard, we performed subcellular fractionation of proteins from B. jararaca snake venom gland, focusing on nuclear proteins since this cellular compartment comprises key effectors that shape gene expression. Our results provided a snapshot of B. jararaca's subcellular venom gland proteome. They pointed to a 'conserved' proteome core among different life stages (newborn and adult) and between genders (adult male and female).
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:05:34.621.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andre Zelanis
SpeciesList	scientific name: Bothrops jararaca (Jararaca) (Bothrops jajaraca); NCBI TaxID: 8724;
ModificationList	monohydroxylated residue; formylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-17 08:28:04	ID requested
1	2023-09-30 05:29:37	announced
⏵ 2	2023-11-14 09:05:35	announced	2023-11-14: Updated project metadata.

Camacho MF, Stuginski DR, Andrade-Silva D, Nishiyama-Jr MY, Valente RH, Zelanis A, A snapshot of Bothrops jararaca snake venom gland subcellular proteome. Biochimie, 214(Pt B):1-10(2023) [pubmed]

submitter keyword: Bothrops jararaca, snake venom, snake venom gland, proteome, subcellular fractionation

André Zelanis
contact affiliation	Functional Proteomics Laboratory, Department of Science and Technology, Federal University of São Paulo, São José dos Campos, SP, Brazil
contact email	andre.zelanis@unifesp.br
lab head
Andre Zelanis
contact affiliation	Laboratory of Functional Proteomics - Department of Science and Technology - Federal University of São Paulo (UNIFESP), Sao Jose dos Campos-SP, Brazil
contact email	zelanis@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD040239

PRIDE project URI

• PRIDE
  1. PXD040239
     1. Label: PRIDE project
     2. Name: A snapshot of Bothrops jararaca snake venom gland subcellular proteome