PXD040224

PXD040224 is an original dataset announced via ProteomeXchange.

Title	Proteomics of 2 postmortem Human Brain Regions for Identification of Cognitive Resilience Factors
Description	We implemented an integrative systems-level analysis of multi-region postmortem human brain proteomics derived from the Religious Order and Rush Memory and Aging Project (ROSMAP) to identify proteins and pathways significantly altered in resilient cases. ROSMAP is an information-rich longitudinal cohort-based study in which participants enroll without dementia, undergo annual cognitive and clinical assessments and donate their brains at death (12). Multiplex tandem mass tag mass spectrometry (TMT-MS)-based proteomic data was implemented for a correlation network analysis. Data from an independent brain proteome wide association study (PWAS) of cognitive trajectory was integrated with the brain network to robustly prioritize protein communities associated with cognitive resilience. This revealed proteins linked to synaptic biology and cellular energetics. Neuritin (NRN1) was prioritized as a hub that co-expressed with a community of proteins with high correlation to cognitive stability in life and is known for important roles in synaptic maturation and stability.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:04:12.598.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eric Dammer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-17 02:23:32	ID requested
1	2023-07-20 20:29:03	announced
⏵ 2	2023-11-14 09:04:16	announced	2023-11-14: Updated project metadata.

Hurst C, Pugh DA, Abreha MH, Duong DM, Dammer EB, Bennett DA, Herskowitz JH, Seyfried NT, Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease. Mol Cell Proteomics, 22(5):100542(2023) [pubmed]

submitter keyword: human brain, DLPFC, iTC, proteome discoverer

Nicholas T. Seyfried, DPhil
contact affiliation	Professor, Emory University School of Medicine Departments of Biochemistry and Neurology
contact email	nseyfri@emory.edu
lab head
Eric Dammer
contact affiliation	Emory University
contact email	edammer@emory.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD040224

PRIDE project URI

• PRIDE
  1. PXD040224
     1. Label: PRIDE project
     2. Name: Proteomics of 2 postmortem Human Brain Regions for Identification of Cognitive Resilience Factors