PXD040214

PXD040214 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Multiomics approaches in Alexander disease zebrafish model show correlation between GFAP aggregation, altered lipid metabolism and oxidative stress
Description	In this work we used our zebrafish model of Alexander Desease (AxD), aiming at unraveling the main pathways involved in AxD pathogenesis performing the first multi-omics analysis on a in vivo model of AxD. The obtained results have been functionally validated and they open the way to further investigation about the involvement of metabolic processes in AxD.
HostingRepository	PRIDE
AnnounceDate	2025-03-13
AnnouncementXML	Submission_2025-03-13_05:44:35.020.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD040214
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Gabriela Coronel Vargas
SpeciesList	scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-16 14:58:48	ID requested
1	2025-03-03 00:55:58	announced
⏵ 2	2025-03-13 05:44:35	announced	2025-03-13: Updated project metadata.

Publication List

Bellitto D, Bozzo M, Ravera S, Bertola N, Rosamilia F, Milia J, Barboro P, Vargas GC, Di Lisa D, Pastorino L, Lantieri F, Castagnola P, Iervasi E, Ponassi M, Profumo A, Tkachenko K, Rosano C, Candiani S, Bachetti T, A multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease. Redox Biol, 81():103544(2025) [pubmed]
10.1016/j.redox.2025.103544;
10.6019/PXD040214;

Bellitto D, Bozzo M, Ravera S, Bertola N, Rosamilia F, Milia J, Barboro P, Vargas GC, Di Lisa D, Pastorino L, Lantieri F, Castagnola P, Iervasi E, Ponassi M, Profumo A, Tkachenko K, Rosano C, Candiani S, Bachetti T, A multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease. Redox Biol, 81():103544(2025) [pubmed]

10.1016/j.redox.2025.103544;

10.6019/PXD040214;

Keyword List

submitter keyword: p.R239C mutation, Danio rerio,Alexander disease, GFAP, zebrafish

submitter keyword: p.R239C mutation, Danio rerio,Alexander disease, GFAP, zebrafish

Contact List

Tiziana Bachetti
contact affiliation	U.O. Proteomica e Spettrometria di Massa Centro Biotecnologie Avanzate (CBA) IRCCS Ospedale Policlinico San Martino, Genova, Italiy
contact email	tiziana.bachetti@hsanmartino.it
lab head
Gabriela Coronel Vargas
contact affiliation	IRCCS Ospedale Policlinico San Martino, Genova
contact email	gabrielafernanda.coronelvargas@edu.unige.it
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD040214
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD040214

PRIDE project URI

Repository Record List

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