PXD040187

PXD040187 is an original dataset announced via ProteomeXchange.

Title	MUSCLE-DERIVED GALECTIN 3 IS A NEW MEDIATOR OF MUSCLE TO BONE CROSSTALK
Description	Galectin-3 is a pleiotropic lectin that regulates multiple cellular processes in a multitude of tissue types. In bone, depending on its cellular localization, Galectin 3 has a dual and opposite role, as if on the one hand intracellular Galectin 3 promotes bone formation, on the other circulating Galectin 3 antagonizes osteoblast differentiation and increases osteoclast activity. In the present study, we demonstrate that Gal-3 is released in the extracellular environment from muscle cultured cells, and reveal the role of Gal-3 in muscle to bone crosstalk, as a factor able to impair bone homeostasis during muscle differentiation and following muscular activity
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:15:33.882.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD040187
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Manuela Piazzi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-16 10:25:16	ID requested
⏵ 1	2025-05-06 09:15:34	announced

Amore E, Cenni V, Piazzi M, Signore M, Orlandi G, Neri S, Biressi S, Barone R, Di Felice V, Follo MY, Bertacchini J, Palumbo C, Myoblast-Derived Galectin 3 Impairs the Early Phases of Osteogenesis Affecting Notch and Akt Activity. Biomolecules, 14(10):(2024) [pubmed]

10.6019/PXD040187;

10.3390/biom14101243;

submitter keyword: Muscle to bone crosstalk,Galectin 3, Proteomics, Bone Remodeling

Jessika Bertacchini
contact affiliation	Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant,Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Italy.
contact email	jessika.bertacchini@unimore.it
lab head
Manuela Piazzi
contact affiliation	Institute of Molecular Genetics - National Research Council of Italy
contact email	manuela.piazzi@cnr.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD040187

PRIDE project URI

• PRIDE
  1. PXD040187
     1. Label: PRIDE project
     2. Name: MUSCLE-DERIVED GALECTIN 3 IS A NEW MEDIATOR OF MUSCLE TO BONE CROSSTALK