PXD040184

PXD040184 is an original dataset announced via ProteomeXchange.

Title	Propionic acid promotes neurite recovery in damaged multiple sclerosis neurons
Description	Neurodegeneration in the autoimmune disease multiple sclerosis (MS) still poses a major therapeutic challenge. Effective drugs that target the inflammation can only partially reduce accumulation of neurological deficits and conversion to progressive disease forms. Diet and the associated gut microbiome are currently being discussed as crucial environmental risk factors that determine disease onset and subsequent progression. In people with MS (pwMS), supplementation of the short-chain fatty acid (SCFA) propionic acid (PA), as microbial metabolite derived from the fermentation of a high-fiber diet, has previously been shown to regulate inflammation accompanied by neuroprotective properties. We set out to determine, whether the neuroprotective impact of PA is a direct mode of action of SCFAs on central nervous system (CNS) neurons.
HostingRepository	PRIDE
AnnounceDate	2024-06-22
AnnouncementXML	Submission_2024-06-22_08:26:02.309.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gereon Poschmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-16 10:13:10	ID requested
⏵ 1	2024-06-22 08:26:03	announced

Gisevius B, Duscha A, Poschmann G, St, ü, hler K, Motte J, Fisse AL, Augustyniak S, Rehm A, Renk P, B, ö, se C, Hubert D, Peters K, Jagst M, G, ö, mer A, Todt D, Bader V, Tokic M, Hirschberg S, Krogias C, Trampe N, Coutourier C, Winnesberg C, Steinmann E, Winklhofer K, Gold R, Haghikia A, Propionic acid promotes neurite recovery in damaged multiple sclerosis neurons. Brain Commun, 6(3):fcae182(2024) [pubmed]

10.1093/braincomms/fcae182;

submitter keyword: propionic acid, neurons, microbiome, iPSCs,multiple sclerosis, damage, neurodegeneration

Gereon Poschmann
contact affiliation	Molecular Proteomics Laboratory Heinrich Heine University Düsseldorf Germany
contact email	gereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliation	Molecular Proteomics Laboratory
contact email	gereon.poschmann@hhu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD040184

PRIDE project URI

• PRIDE
  1. PXD040184
     1. Label: PRIDE project
     2. Name: Propionic acid promotes neurite recovery in damaged multiple sclerosis neurons