PXD040182 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Dosage compensation mass spectrometry in platypus, chicken and mouse |
Description | Gene dosage imbalance of heteromorphic sex chromosomes (XY or ZW) exists between the sexes, and with the autosomes. Mammalian X chromosome inactivation was long thought to imply a critical need for dosage compensation in vertebrates. However, mRNA abundance measurements that demonstrated sex chromosome transcripts are neither balanced between the sexes or with autosomes in monotreme mammals or birds brought sex chromosome dosage compensation into question. This study examines transcriptomic and proteomic levels of dosage compensation in platypus and chicken compared to mouse, a model eutherian species. We analyzed mRNA and protein levels in heart and liver tissues of chicken, mouse and platypus. |
HostingRepository | PRIDE |
AnnounceDate | 2024-07-30 |
AnnouncementXML | Submission_2024-07-30_04:29:15.514.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Nicholas Lister |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Gallus gallus (Chicken); NCBI TaxID: 9031; scientific name: Ornithorhynchus anatinus; NCBI TaxID: 9258; |
ModificationList | iTRAQ4plex-116 reporter+balance reagent acylated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-02-16 10:12:31 | ID requested | |
⏵ 1 | 2024-07-30 04:29:15 | announced | |
Publication List
Keyword List
submitter keyword: heart,Platypus, dosage compensation, liver, chicken, mouse |
Contact List
Paul D. Waters |
contact affiliation | BABS, UNSW Sydney, Australia |
contact email | p.waters@unsw.edu.au |
lab head | |
Nicholas Lister |
contact affiliation | UNSW |
contact email | n.lister@unsw.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040182
- Label: PRIDE project
- Name: Dosage compensation mass spectrometry in platypus, chicken and mouse