PXD040182

PXD040182 is an original dataset announced via ProteomeXchange.

Title	Dosage compensation mass spectrometry in platypus, chicken and mouse
Description	Gene dosage imbalance of heteromorphic sex chromosomes (XY or ZW) exists between the sexes, and with the autosomes. Mammalian X chromosome inactivation was long thought to imply a critical need for dosage compensation in vertebrates. However, mRNA abundance measurements that demonstrated sex chromosome transcripts are neither balanced between the sexes or with autosomes in monotreme mammals or birds brought sex chromosome dosage compensation into question. This study examines transcriptomic and proteomic levels of dosage compensation in platypus and chicken compared to mouse, a model eutherian species. We analyzed mRNA and protein levels in heart and liver tissues of chicken, mouse and platypus.
HostingRepository	PRIDE
AnnounceDate	2024-07-30
AnnouncementXML	Submission_2024-07-30_04:29:15.514.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nicholas Lister
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Gallus gallus (Chicken); NCBI TaxID: 9031; scientific name: Ornithorhynchus anatinus; NCBI TaxID: 9258;
ModificationList	iTRAQ4plex-116 reporter+balance reagent acylated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-16 10:12:31	ID requested
⏵ 1	2024-07-30 04:29:15	announced

10.1073/PNAS.2322360121;

submitter keyword: heart,Platypus, dosage compensation, liver, chicken, mouse

Paul D. Waters
contact affiliation	BABS, UNSW Sydney, Australia
contact email	p.waters@unsw.edu.au
lab head
Nicholas Lister
contact affiliation	UNSW
contact email	n.lister@unsw.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD040182

PRIDE project URI

• PRIDE
  1. PXD040182
     1. Label: PRIDE project
     2. Name: Dosage compensation mass spectrometry in platypus, chicken and mouse