PXD040165

PXD040165 is an original dataset announced via ProteomeXchange.

Title	Evaluation of EVE peptidome presentation on B16 cell line and tumors
Description	Cancer immunotherapies have greatly improved the treatment of several solid cancers, albeit a large fraction of the patients still does not benefit from such treatments. Personalized therapies are envisioned to lead to improved outcomes yet they have largely been leveraging neoepitopes arising from missense somatic mutations, and as such primarily patients with relatively high tumor mutational burden (TMB) are eligible. With the goal to enhance and broaden its application, we here submit our results regarding our murine B16 studies with a focus on endogenous viral elements (EVE) derived peptidome. We observe how external signal or tumor microenvironment can alter this tumor model EVE presentation, while also keeping a significant overlap of EVE ligands across all biological treatments.
HostingRepository	PRIDE
AnnounceDate	2025-03-21
AnnouncementXML	Submission_2025-03-21_02:48:16.272.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pablo Garces
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; deamidated residue
Instrument	ultraflex; TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-16 09:52:09	ID requested
⏵ 1	2025-03-21 02:48:16	announced

10.1038/S41541-025-01107-Y;

submitter keyword: Endogenous viral elements, B16, melanoma, tumor, EVEs,Murine

Anthony W. Purcell
contact affiliation	Monash University
contact email	Anthony.Purcell@monash.edu
lab head
Pablo Garces
contact affiliation	Evaxion-biotech
contact email	paga@evaxion-biotech.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD040165

PRIDE project URI

• PRIDE
  1. PXD040165
     1. Label: PRIDE project
     2. Name: Evaluation of EVE peptidome presentation on B16 cell line and tumors