Update information. The 4D label-free quantitative proteomics (4D-LFQ) was used for quantification of proteome changes. Enrichment of phosphorylated peptides using immobilized metal ion affinity chromatography (IMAC) and enrichment of ubiquitinated peptides using anti-diglycine remnant (anti-K-ε-GG) antibodywere performed in phosphoproteome and ubiquitylome, respectively. Phosphorylation and ubiquitination quantifications were normalized by protein quantifications to eliminate the interference caused by protein abundance differences.