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PXD040122

PXD040122 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePolyhexamethylene guanidine aerosol causes irreversible changes in blood proteins that associated with the severity of lung injury
DescriptionHumidifier disinfectant (HD)-associated lung injury (HDLI) not only associates with increased acute morbidity and mortality, but also affects long term lung function due to lung fibrosis. However, there have been no validated marker capable of detecting exposure to HDs or severity of HDLI. This study aims to discover the differential abundant plasma proteome between them and develop prediction score platform using plasma proteome data from HD-exposed patients in order to classify the severity of HDLI. A total of 483 samples were used in this study. The samples used were 162 children in the normal group, 76 in the 4th stage, 51 in the 3rd stage, 54 in the 2nd stage, 42 in the 1st stage and 50 female adults in the normal group, 20 in the 4th stage, 7 in the 3rd stage, 6 in the 2nd stage, and 14 in 1st stage. The lower the grade, the greater the severity of HDLI.
HostingRepositoryPRIDE
AnnounceDate2024-08-14
AnnouncementXMLSubmission_2024-08-14_05:48:55.052.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHee-Sung Ahn
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-02-15 05:38:06ID requested
12024-08-14 05:48:55announced
Publication List
10.1016/j.jhazmat.2024.135359;
Ahn HS, Lee SY, Kang MJ, Hong SB, Song JW, Do KH, Yeom J, Yu J, Oh Y, Hong JY, Chung EH, Kim K, Hong SJ, Polyhexamethylene guanidine aerosol causes irreversible changes in blood proteins that associated with the severity of lung injury. J Hazard Mater, 478():135359(2024) [pubmed]
Keyword List
submitter keyword: LC-MSMS, lung injury, chemically-induced disorders;, SWATH-MS, Disinfectants,Human Plasma
Contact List
Kyunggon Kim
contact affiliationDepartment of Convergence Medicine, Convergence Medicine Research Center/Biomedical Research Center, Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
contact emailkkkon1@amc.seoul.kr
lab head
Hee-Sung Ahn
contact affiliationAsan Medical Center
contact emailzaulim3@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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