PXD040112

PXD040112 is an original dataset announced via ProteomeXchange.

Title	Cognitive impairment in methamphetamine-dependent individuals
Description	Methamphetamine (METH) is a drug with high abuse potential that directly affects the central nervous system. METH use leads not only to detrimental health for the user but also to potential risks and costs for society. Impaired cognition has been shown to exist in individuals with long-term METH dependence, and this impairment may be the main cause of impulsive drug taking and high relapse rate. However, the molecular mechanisms underlying METH addiction and METH-induced cognitive decline remain unknown. To investigate potential molecular mechanisms of METH addiction, we compared serum protein expression levels by using label-free quantitative proteomics in 12 long-term METH users and 12 healthy control participants. In total, 23 differentially expressed proteins were found between the two groups. Bioinformatics analyses were used to identify functional networks and protein-protein interactions. The differentially expressed proteins were related to cognitive dysfunction, inflammation of the nervous system, immune system decline, energy metabolism, and calcium binding and regulation. Thus, these 23 proteins may be closely associated with the damage caused by METH to the nervous, immune, and metabolic systems. The results of this study provide additional insights into the molecular mechanisms of METH addiction and potential prevention and treatment options for METH-dependent individuals.
HostingRepository	iProX
AnnounceDate	2023-02-14
AnnouncementXML	Submission_2023-02-13_23:40:42.474.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yongchao Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-13 23:40:27	ID requested
⏵ 1	2023-02-13 23:40:42	announced

Dataset with its publication pending

submitter keyword: Addiction, Cognitive disorder, Label-free proteomics, Methamphetamine

Chenglin Zhou
contact affiliation	Shanghai University of Sport
contact email	Chenglin_600@126.com
lab head
Yongchao Li
contact affiliation	State Intellectual Property Office
contact email	leeych2006@aliyun.com
dataset submitter

iProX dataset URI