PXD040101

PXD040101 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	LC-MSMS analysis of plasma from multiple sclerosis-affected patients
Description	Multiple sclerosis (MS) is a common autoimmune and degenerative disorder caused by chronic inflammatory reactions in the central nervous system. However, little is known about the changes of plasma proteomic profiles in Chinese patients with MS (CpwMS), and potential molecular networks that underlie the etiology of MS. This study seeks to uncover the characteristics of proteomics landscape in CpwMS, and reveal potential biomarkers and the underlying pathological molecular networks that might promote MS etiopathology. Plasma samples were collected from 22 CpwMS and 22 healthy controls (HCs) and analyzed using a Tandem Mass Tag (TMT)-based quantitative proteomics approach. Results showed that the plasma proteomics pattern was significantly different in CpwMS compared to HCs. A total of 90 significantly and differentially expressed proteins (P < 0.05) were identified in CpwMS plasma comparing to HCs.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:16:26.047.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD040101
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Shan Chao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-13 10:30:00	ID requested
⏵ 1	2025-05-06 09:16:26	announced

Publication List

Yang F, Zhao LY, Yang WQ, Chao S, Ling ZX, Sun BY, Wei LP, Zhang LJ, Yu LM, Cai GY, Quantitative proteomics and multi-omics analysis identifies potential biomarkers and the underlying pathological molecular networks in Chinese patients with multiple sclerosis. BMC Neurol, 24(1):423(2024) [pubmed]
10.6019/PXD040101;
10.1186/s12883-024-03926-3;

Yang F, Zhao LY, Yang WQ, Chao S, Ling ZX, Sun BY, Wei LP, Zhang LJ, Yu LM, Cai GY, Quantitative proteomics and multi-omics analysis identifies potential biomarkers and the underlying pathological molecular networks in Chinese patients with multiple sclerosis. BMC Neurol, 24(1):423(2024) [pubmed]

10.6019/PXD040101;

10.1186/s12883-024-03926-3;

Keyword List

submitter keyword: Proteomic profile
LC-MSMS
Differentially expressed protein
Plasma
Multiple sclerosis
Potential biomarker

submitter keyword: Proteomic profile

LC-MSMS

Differentially expressed protein

Plasma

Multiple sclerosis

Potential biomarker

Contact List

Fan Yang
contact affiliation	Shanghai Jiao Tong University
contact email	yangfan_sjtu@sjtu.edu.cn
lab head
Shan Chao
contact affiliation	Engineer
contact email	bicyclecad@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD040101
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD040101

PRIDE project URI

Repository Record List

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