PXD040093 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The effects of silencing PCYOX1 on the proteome of mitochondria isolated from murine cardiomyocites HL-1 |
| Description | In order to evaluate the impact of PCYOX1 deletion on cardiomyocytes, we applied a label-free mass spectrometry-based proteomic approach to compare the proteome of mitochondria from Hl-1 after PCYOX1 gene silencing. Pcyox1 was silenced using shRNA lentiviral particles. Control cells were treated with shRNA lentiviral particles containing a negative construct. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-27 |
| AnnouncementXML | Submission_2026-04-26_17:16:17.412.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD040093 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Erica Gianazza |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Synapt MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-02-13 03:35:25 | ID requested | |
| ⏵ 1 | 2026-04-26 17:16:18 | announced | |
Publication List
| Banfi C, Brocca L, Bascucci A, Papaianni GG, Mallia A, Eligini S, Prenylcysteine Oxidase 1 Deficiency Protects the Cardiac Muscle Cell Line HL-1 Against Ischaemic/Hypoxic Stress. FASEB J, 40(8):e71819(2026) [pubmed] |
| 10.6019/PXD040093; |
| 10.1096/fj.202502993r; |
Keyword List
| submitter keyword: label-free mass spectrometry, mitochondria, HL1 cells,PCYOX1 |
Contact List
| Cristina Banfi |
|---|
| contact affiliation | Proteomics and Metabolomics Unit, Monzino Cardiologic Center, IRCCS, Milan, Italy |
| contact email | cristina.banfi@cardiologicomonzino.it |
| lab head | |
| Erica Gianazza |
|---|
| contact affiliation | Centro Cardiologico Monzino |
| contact email | erica.gianazza@cardiologicomonzino.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD040093 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040093
- Label: PRIDE project
- Name: The effects of silencing PCYOX1 on the proteome of mitochondria isolated from murine cardiomyocites HL-1
