PXD040038

PXD040038 is an original dataset announced via ProteomeXchange.

Title	High throughput plasma proteomics profiling reveals metabolic and immunologic differences between anorexia nervosa subtypes
Description	Anorexia nervosa (AN) is a severe psychiatric disorder of an unknown aetiology with a mortality rate of 5% per year, making it one of the most deadly of all psychiatric illnesses. Despite extensive research efforts in recent years, the underlying pathophysiology of AN remains poorly understood. In this study, we aimed to identify novel protein biomarkers for AN by performing a proteomics analysis of plasma samples from 77 females with AN (56 restrictive and 21 binge-purge type) and 70 healthy controls. Using state-of-the-art mass spectrometry-based proteomics technology in conjunction with an advanced bioinformatics pipeline, we quantify more than 500 plasma proteins. Our differential expression analysis and correlation of proteomics data with clinical parameters led to identification of a panel of novel protein biomarkers with potential pathophysiological significance for AN. Our findings demonstrate evidence of a humoral immune system response, altered lipid metabolism and potential dysregulation of plasma cells in AN patients. Additionally, we stratified AN patients based on the quantified proteins and suggest potential auto-immune nature of disease in restrictive subtype. In summary, this study provides a comprehensive map of plasma proteins that may have utility in further understanding the pathophysiology of AN.
HostingRepository	PRIDE
AnnounceDate	2024-01-10
AnnouncementXML	Submission_2024-01-10_02:47:07.047.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Diana Samodova-Sommer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-10 06:52:18	ID requested
⏵ 1	2024-01-10 02:47:07	announced

10.1016/J.METABOL.2023.155760;

submitter keyword: Human, Plasma, Anorexia nervosa, Proteomics, LC-MS/MS

Atul Shahaji Deshmukh
contact affiliation	Assoc. Prof. at Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
contact email	atul.deshmukh@sund.ku.dk
lab head
Diana Samodova-Sommer
contact affiliation	Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
contact email	diana.samodova@sund.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD040038

PRIDE project URI

• PRIDE
  1. PXD040038
     1. Label: PRIDE project
     2. Name: High throughput plasma proteomics profiling reveals metabolic and immunologic differences between anorexia nervosa subtypes