PXD040019

PXD040019 is an original dataset announced via ProteomeXchange.

Title	Trypanosomatid extracellular vesicles as potential immunogens in Chagas disease
Description	Extracellular vesicles (EVs) from parasite protozoa can induce efficient immunity, which makes them useful for probable next-generation vaccines, more specifically against Trypanosoma cruzi infection. Howevver, the mechanisms involved in the protective responses have not been fully elucidated. To investigate the potential use of trypanosomatid EVs as immunogens against Chagas disease we tested the effect of EVs stimulation from Trypanosoma rangeli and Phytomonas serpens compared to T. cruzi response in vitro and in vivo, besides performing a proteomics evaluation of the EVs.Overall, our results pointed out that EVs of T. cruzi-correlated parasites have antigenic potential. Despite minor effects in the modulation of antigen presentation cells surface receptors and in in vitro T. cruzi infection, T. rangeli and P. serpens EVs can contribute to reducing T. cruzi infectivity in Balb/c mice.
HostingRepository	PRIDE
AnnounceDate	2025-01-21
AnnouncementXML	Submission_2025-01-21_05:15:52.251.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD040019
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Michel Batista
SpeciesList	scientific name: Phytomonas serpens; NCBI TaxID: 5707; scientific name: Trypanosoma cruzi Dm28c; NCBI TaxID: 1416333; scientific name: Trypanosoma rangeli; NCBI TaxID: 5698;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap XL ETD

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-10 04:48:48	ID requested
⏵ 1	2025-01-21 05:15:52	announced

10.6019/PXD040019;

submitter keyword: immunogens,Trypanosomatid, extracellular vesicles, Chagas disease

Pryscilla Fanini Wowk
contact affiliation	Carlos Chagas Institute, Fiocruz Parana, Brazil
contact email	pryscilla.wowk@fiocruz.br
lab head
Michel Batista
contact affiliation	Fiocruz
contact email	batista.mic@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD040019
     1. Label: PRIDE project
     2. Name: Trypanosomatid extracellular vesicles as potential immunogens in Chagas disease