PXD039998

PXD039998 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	EP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer
Description	Ferroptosis is a form of regulated cell death characterized by oxidative injury-induced lipid peroxidation. However, the detailed protein post-translational modification regulatory mechanism of ferroptosis remains largely unknown. Here, we report that E1A binding protein P300 (EP300) acetyltransferase promotes ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cells via the acetylation of heat shock protein family A (Hsp70) member 5 (HSPA5, also known as GRP78 or BIP) on the site of K353. Acetylated HSPA5 loses its ability to inhibit lipid peroxidation and subsequent ferroptotic cell death. Genetic or pharmacological inhibition of EP300-mediated HSPA5 acetylation on K353 increases PDAC cell resistance to ferroptosis. Moreover, histone deacetylase 6 (HDAC6) limits HSPA5 acetylation and subsequent ferroptosis.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:09:19.534.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuan Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-09 01:55:46	ID requested
1	2023-10-24 11:49:35	announced
2	2023-11-14 09:07:57	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 06:09:20	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/s41598-023-42136-8;
Wang Y, Liu Y, Wang C, Kang R, Tang D, Liu J, EP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer. Sci Rep, 13(1):15004(2023) [pubmed]

10.1038/s41598-023-42136-8;

Wang Y, Liu Y, Wang C, Kang R, Tang D, Liu J, EP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer. Sci Rep, 13(1):15004(2023) [pubmed]

Keyword List

submitter keyword: Human, Cell, IP-MS, PDAC

submitter keyword: Human, Cell, IP-MS, PDAC

Contact List

Jiao Liu
contact affiliation	The Third Affiliated Hospital of Guangzhou Medical University
contact email	641504008@qq.com
lab head
Yuan Wang
contact affiliation	The Third Affiliated Hospital of Guangzhou Medical University
contact email	1067163037@qq.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD039998
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD039998

PRIDE project URI

Repository Record List

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