PXD039949

PXD039949 is an original dataset announced via ProteomeXchange.

Title	Top-down proteomics of membrane proteoforms from HeLa cells and mouse hippocampus
Description	Comprehensive characterization of membrane proteins at the level of proteoforms in complex biological samples by top-down mass spectrometry is of vital importance in revealing their precise functions. Based on a novel membrane protein separation technology, we obtained a dataset of membrane proteoforms from HeLa cells and mouse hippocampus, containing information about combinatorial post-translational modifications, truncation, and complete transmembrane domains, which accelerate our understanding and exploitation of membrane proteins.
HostingRepository	iProX
AnnounceDate	2023-02-08
AnnouncementXML	Submission_2024-12-02_18:03:15.604.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yue Sun
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	acetylated residue; phosphorylated residue; monomethylated residue; oxidation
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-08 03:06:37	ID requested
⏵ 1	2024-12-02 18:03:16	announced

Sun Y, Liang Y, Wang C, Zhao B, Liang Z, Zhang X, Zhang Y, Zhang L, Enhancing Top-Down Characterization of Membrane Proteoforms with C8-Functional Amine-Bridged Hybrid Monoliths. Anal Chem, 95(17):6846-6853(2023) [pubmed]

submitter keyword: membrane protein, proteoforms, Top-down proteomics

Lihua Zhang
contact affiliation	Dalian Institute of Chemical Physics, Chinese Academy of Sciences
contact email	lihuazhang@dicp.ac.cn
lab head
Yue Sun
contact affiliation	Dalian Institute of Chemical Physics, Chinese Academy of Sciences&University of Chinese Academy of Sciences
contact email	yuesun@dicp.ac.cn
dataset submitter

iProX dataset URI