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PXD039923

PXD039923 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic comparison of human milk, cow's milk and infant formula extracellular vesicles
DescriptionMilk and milk products such as infant formula (IF) play a fundamental role in serving the nutritional needs of the developing infant. Extracellular vesicles (EVs) in human (HM) and cow’s milk (CM) contain molecular cargo such as proteins and micro(mi)RNA that serve as functional messengers between cells and may be of importance to infant health. Here, we have developed a pipeline using advanced proteomics and transcriptomics to enable cross-species comparison of milk and IF EVs. EVs from HM, CM and IF were subjected to data-independent acquisition mass spectrometry and RNA-seq. Differentially abundant proteins (143) and miRNAs (514) (false discovery rate < 0.01) were identified in HM and CM EVs, and CM EV proteins and miRNAs were conserved in IF EVs (~20-90%). We foresee this work to be used in large scale studies to determine biologically relevant species-specific differences in milk EVs that could be leveraged to improve IF products.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_06:50:27.884.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNatalie Turner
SpeciesList scientific name: Bos taurus (Bovine); NCBI TaxID: 9913; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-02-07 14:05:48ID requested
12023-08-13 08:06:08announced
22023-11-14 06:50:28announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: milk
infant formula
extracellular vesicles
proteomics
SWATH
mass spectrometry
transcriptomics
Contact List
Murray D. Mitchell
contact affiliationCentre for Children's Health Research (CCHR) Queensland University of Technology 62 Graham Street South Brisbane, QLD 4101 AUSTRALIA
contact emailmurray.mitchell@qut.edu.au
lab head
Natalie Turner
contact affiliationQueensland University of Technology
contact emailnatalie.turner@hdr.qut.edu.au
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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