PXD039819

PXD039819 is an original dataset announced via ProteomeXchange.

Title	Adaptation of the epigenetic regulatory network to the loss of ARID1A and CREBBP
Description	Epigenetic regulators (ERs) have a central role in regulating gene expression to define cell identity and are amongst the most frequently mutated genes in cancer. However, epigenetic regulators are rarely cell-essential, and in large CRISPR screening projects, human cell lines tolerate the knockout of many key epigenetic regulators with only minor effects on growth. These results indicate that human cells are robust to epigenetic disruption, but how epigenetic pathways interact to form a robust regulatory network is not understood. We are studying the loss of ARID1A and CREBBP, two important ERs that are frequently mutated in multiple cancer types. We analyzed histone post-translational modifications in ARID1A and CREBBP knockout lines in two normal (non-cancerous) human epithelial cell types, HME1 (ATCC, normal human breast epithelia) and HCEC-1CT (Evercyte, normal human colon epithelial).
HostingRepository	PRIDE
AnnounceDate	2025-04-07
AnnouncementXML	Submission_2025-04-06_23:49:09.216.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roberta Noberini
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monomethylated residue; acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-03 02:29:23	ID requested
⏵ 1	2025-04-06 23:49:09	announced

10.1093/NAR/GKAF297;

submitter keyword: histone post-translational modifications

Tiziana Bonaldi
contact affiliation	European Institute of Oncology
contact email	tiziana.bonaldi@ieo.it
lab head
Roberta Noberini
contact affiliation	Istituto Europeo di Oncologia
contact email	roberta.noberini@ieo.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD039819

PRIDE project URI

• PRIDE
  1. PXD039819
     1. Label: PRIDE project
     2. Name: Adaptation of the epigenetic regulatory network to the loss of ARID1A and CREBBP