PXD039807

PXD039807 is an original dataset announced via ProteomeXchange.

Title	Global molecular response of Paracoccidioides brasiliensis to zinc deprivation: analyses at transcript, protein and microRNA levels.
Description	Zinc is one of the main micronutrients for all organisms. One of the defense mechanisms used by the host includes the sequestration of metals used in fungal metabolism, such as iron and zinc. There are several mechanisms that maintain the balance in intracellular zinc supply. MicroRNAs are effector molecules of responses between pathogen and host, favoring or preventing infection in many mi-croorganisms. Fungi of the Paracoccidioides genus are thermodimorphic and the etiological agents of paracoccidioidomycosis (PCM). In the current pandemic scenario in which the world mycosis studies continue to be highly important since a significant number of patients with COVID-19 developed systemic mycoses, co-infections that complicated their clinical condition. The objective is to identify transcriptomic and proteomic adaptations in Paracoccidioides brasiliensis during zinc deprivation. Nineteen microRNAs were identified, three of which were differentially regulated. Target genes regulated by those microRNAs are elements of zinc homeostasis such as ZRT1, ZRT3 and COT1 transporters. Transcription factors that have zinc in their structure are also targets of those miRNAs. Transcriptional and proteomic data suggest that P. brasiliensis undergoes metabolic remodeling to survive zinc deprivation and that miRNAs may be part of the regulatory process
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:45:36.402.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexandre Bailao
SpeciesList	scientific name: Paracoccidioides brasiliensis (strain Pb18); NCBI TaxID: 502780;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-02 08:32:26	ID requested
1	2023-05-10 08:51:39	announced
⏵ 2	2023-11-14 08:45:44	announced	2023-11-14: Updated project metadata.

Mesquita LA, Bail, ã, o AM, de Curcio JS, da Silva KLP, da Rocha Fernandes G, Silva-Bail, ã, o MG, Novaes E, de Almeida Soares CM, to Zinc Deprivation: Analyses at Transcript, Protein and MicroRNA Levels. J Fungi (Basel), 9(3):(2023) [pubmed]

submitter keyword: Zinc

miRNA

proteomics

transcriptomics

Célia Maria de Almeida Soares
contact affiliation	Universidade Federal de Goiás
contact email	cmasoares@gmail.com
lab head
Alexandre Bailao
contact affiliation	Universidade Federal de Goiás
contact email	alexandre.bailao@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD039807

PRIDE project URI

• PRIDE
  1. PXD039807
     1. Label: PRIDE project
     2. Name: Global molecular response of Paracoccidioides brasiliensis to zinc deprivation: analyses at transcript, protein and microRNA levels.