PXD039791

PXD039791 is an original dataset announced via ProteomeXchange.

Title	Identification of novel urine proteomic biomarkers for high stamina in high-altitude adaptation
Description	Ascending to high-altitude of non-high-altitude natives showed rapidly declined physical ability, but some with high-altitude adaptability were still able to maintain a high level. Our goal was to find urine biomarkers that could be used to assess people for high-altitude hypoxia adaptation with high stamina. Blood routine tests were done for HH (High-altitude with high stamina) and HL (High-altitude with low stamina) groups at high altitude and at sea level. By contrasting urine peptidome profiling between the HH and HL groups, urine biomarkers were discovered. Blood routine tests showed that WBC, LYM, and PLT concentrations were considerably greater in HH than in HL. Four proteins have significantly different levels of expression between HH and HL, according to urine peptidome profiling. Expression of these proteins were tested by ELISA in HH and HL samples. Our study provided a novel approach for identifying potential biomarkers for screening people who can adapt to high altitudes with high stamina.
HostingRepository	iProX
AnnounceDate	2023-02-02
AnnouncementXML	Submission_2024-03-20_00:12:01.882.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chunlei Liu
SpeciesList	scientific name: Human parechovirus strain T82-0169; NCBI TaxID: 1001056;
ModificationList	N-acetylated residue
Instrument	Proteomics Standards Initiative Mass Spectrometry Vocabularies

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-01 19:13:29	ID requested
⏵ 1	2024-03-20 00:12:03	announced

Liu C, Guo G, Li X, Shen Y, Xu X, Chen Y, Li H, Hao J, He K, Identification of novel urine proteomic biomarkers for high stamina in high-altitude adaptation. Front Physiol, 14():1153166(2023) [pubmed]

submitter keyword: Urine biomarkers1, Proteomic2, High stamina3, High-altitude adaptation4, Blood routine tests5.

Kunlun He
contact affiliation	Chinese PLA general hospital
contact email	hekl301@163.com
lab head
Chunlei Liu
contact affiliation	Chinese PLA general hospital
contact email	liuchunlei19870201@163.com
dataset submitter

iProX dataset URI