PXD039748

PXD039748 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics reveals the disturb of kinase-substrates in intracerebral hemorrhage with hyperhomocysteinaemia
Description	To elucidate the impact and mechanism of homocysteine on intracerebral hemorrhage at a system-wide level, we used a global phosphoproteomic approach combined with proteomics. Hyperhomocysteinaemia (HHcy) mice was induced by high methionine diet，and Experimental intracerebral hemorrhage was induced by injection of autologous blood. Perihematoma tissue was collected and MS/MS was performed to get phophoproteomics data.
HostingRepository	iProX
AnnounceDate	2023-01-31
AnnouncementXML	Submission_2023-12-04_21:11:09.914.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guangyu Guo
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-30 23:41:33	ID requested
1	2023-01-30 23:41:45	announced
⏵ 2	2023-12-04 21:11:10	announced	2023-12-05: Update publication information.

Guo G, Yang J, Guo W, Deng H, Yu H, Bai S, Li G, Tang Y, Zhang P, Xu Y, Pan C, Tang Z, Homocysteine impedes neurite outgrowth recovery after intracerebral haemorrhage by downregulating pCAMK2A. Stroke Vasc Neurol, 8(4):335-348(2023) [pubmed]

submitter keyword: Phosphoproteomics, Intracerebral hemorrhage, Homocysteinaemia

Zhouping Tang
contact affiliation	Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
contact email	ddjtzp@163.com
lab head
Guangyu Guo
contact affiliation	Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
contact email	guangyuguoer@163.com
dataset submitter

iProX dataset URI