PXD039745
PXD039745 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma glycoproteomic profiling characterization of glycosylation biomarkers for HCC diagnosis |
| Description | Hepatocellular carcinoma (HCC) is a life-threatening disease. Due to the lack of reliable diagnostic biomarkers, the diagnosis of this disease is challenging. Recently, plasma glycoproteomics has emerged as a powerful tool for the identifying disease diagnostic biomarkers. Here, we performed a comprehensive proteomic and glycoproteomic analysis in the plasma of 12 HCC patients and 12 healthy control (HC) individuals. We identified 20 signature proteins and 32 signature IGPs that can distinguish HCC from HC effectively. Moreover, we demonstrated that IGPs profiles could be better predictive biomarkers for screening HCC than protein profiles. Pathways for signature proteins and IGPs were illustrated. For the first time, we showed that the protein expression level of LGALS3BP, as well as its N-linked glycosylation at the N511/398 sites could be a valuable diagnosis biomarker of HCC. Overall, our data suggest a major role for glycoproteomics in understanding HCC, and presents a number of new biomarkers for future |
| HostingRepository | iProX |
| AnnounceDate | 2023-05-09 |
| AnnouncementXML | Submission_2023-05-08_19:17:13.768.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | JiaMing Zeng |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos; Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-01-30 20:38:46 | ID requested | |
| ⏵ 1 | 2023-05-08 19:17:14 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Hepatocellular carcinoma, glycoproteomics, biomarker, diagnosis |
Contact List
| Yang Zhao | |
|---|---|
| contact affiliation | National Institute of Metrology, Shenyang University of Chemical Technology |
| contact email | zhaoy@nim.ac.cn |
| lab head | |
| JiaMing Zeng | |
| contact affiliation | National Institute of Metrology, Shenyang University of Chemical Technology |
| contact email | zjm1412103444@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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