PXD039727

PXD039727 is an original dataset announced via ProteomeXchange.

Title	Dendrobium mixture ameliorates non-alcoholic fatty liver disease induced by type 2 diabetes mellitus through PPAR gamma: an integrated study of bioinformatics analysis and experimental verification
Description	Dendrobium mixture (DM) is a patented Chinese herbal medicine indicated which has anti inflammatory and improved glycolipid metabolism. However, its active ingredients, targets of action, and potential mechanisms are still uncertain. Here, we investigate the role of DM as a prospective modulator of protection against nonalcoholic fatty liver disease (NAFLD) induced by type 2 diabetes mellitus (T2DM) and illustrate the molecular mechanisms potentially involved. The network pharmacology and TMT-based quantitative protomics analysis were conducted to identify potential gene targets of the active ingredients in DM against NAFLD and T2DM. DM was administered to the mice of DM group for 4 weeks, and db/m mice (control group) and db/db mice (model group) were gavaged by normal saline.Besides, db/db mice(Metformin group) were gavaged by Metformin.
HostingRepository	iProX
AnnounceDate	2023-01-28
AnnouncementXML	Submission_2023-03-09_18:54:17.046.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuting Zhuang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-28 18:11:23	ID requested
1	2023-02-14 03:58:35	announced
⏵ 2	2023-03-09 18:54:18	announced	2023-03-10: Update publication information.

Zhuang S, Zhang J, Lin X, Wang X, Yu W, Shi H, Dendrobium mixture ameliorates type 2 diabetes mellitus with non-alcoholic fatty liver disease through PPAR gamma: An integrated study of bioinformatics analysis and experimental verification. Front Pharmacol, 14():1112554(2023) [pubmed]

submitter keyword: Dendrobium mixture, Non-alcoholic fatty liver disease, Type 2 diabetes mellitus, Network pharmacology, TMT-based quantitative proteomics

Hong Shi
contact affiliation	Fujian University of Traditional Chinese Medicine
contact email	shihong@fjtcm.edu.cn
lab head
Shuting Zhuang
contact affiliation	Fujian University of Traditional Chinese Medicine
contact email	18344981481@163.com
dataset submitter

iProX dataset URI