PXD039726
PXD039726 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | TEAD inhibitor K-975 enhances KRASG12C inhibitor adagrasib-mediated cancer cell proliferation inhibition via dual cell cycle arrest |
Description | Here we investigate the effect of the dual inhibition, in KRASG12C mutated NSCLC cells, using the KRASG12Ci adagrasib (MRTX849) and the pan-TEAD inhibitor (TEADi) K-975. We show that K-975 enhances adagrasib-induced tumor cell growth inhibition in cancer cells. Mechanistically, we detect a downregulation of MYC and E2F signatures and a downregulation of the G2/M checkpoint regulation, which result in the increase of G1 and the decrease of the G2/M cell cycle phases. These data suggest that the co-inhibition of KRASG12C and YAP1-TEAD leads to a specific switch in the mechanism of cancer cell killing. |
HostingRepository | jPOST |
AnnounceDate | 2023-05-12 |
AnnouncementXML | Submission_2023-05-12_06:47:45.142.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Armelle BUZY |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; 2-pyrrolidone-5-carboxylic acid (Gln); L-methionine sulfoxide |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-01-28 04:37:56 | ID requested | |
⏵ 1 | 2023-05-12 06:47:46 | announced |
Publication List
Tammaccaro SL, Prigent P, Le Bail JC, Dos-Santos O, Dassencourt L, Eskandar M, Buzy A, Venier O, Guillemot JC, Veeranagouda Y, Didier M, Spanakis E, Kanno T, Cesaroni M, Mathieu S, Canard L, Casse A, Windenberger F, Calvet L, Noblet L, Sidhu S, Debussche L, Moll J, Valtingojer I, -Mutant NSCLC. Pharmaceuticals (Basel), 16(4):(2023) [pubmed] |
Keyword List
submitter keyword: TEAD, KRAS Quantitative Proteomics |
Contact List
Iris Valtingojer | |
---|---|
lab head | |
Armelle BUZY | |
contact affiliation | SANOFI |
dataset submitter |
Full Dataset Link List
jPOST dataset URI |
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