PXD039724
PXD039724 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics coupled transcriptomics reveals lipopolysaccharide inhibiting peroxisome proliferator-activated receptors signalling pathway to reduce lipid droplets accumulation in mouse liver |
| Description | Lipid droplets (LDs) are multifunctional organelles consisting of a central compartment of non-polar lipids shielded from the cytoplasm by a phospholipid monolayer. The excessive accumulation of lipid droplets in cells is closely related to the development and progression of many diseases in humans and animals, such as liver-related and cardiovascular diseases. Thus, regulating the LDs size and abundance is necessary to maintain metabolic homeostasis. In this study, we found that LPS stimulation reduced the LDs content in the mouse liver. We tried to explain the possible molecular mechanisms at the broad protein and mRNA levels, finding that inhibition of the peroxisome proliferator-activated receptors (PPAR) signalling pathway by LPS may be a critical factor in reducing LDs content. |
| HostingRepository | iProX |
| AnnounceDate | 2023-01-27 |
| AnnouncementXML | Submission_2024-02-03_20:36:27.130.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiangbei Yuan |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-01-27 18:26:25 | ID requested | |
| 1 | 2023-01-27 18:26:47 | announced | |
| ⏵ 2 | 2024-02-03 20:36:28 | announced | 2024-02-04: Update publication information. |
Publication List
| Ran H, Sun W, Wang L, Wang X, Yu H, Chen J, Liu F, Chao Z, Pu Q, Liu Y, Zeng Y, Li Z, Wan Y, Yuan J, Proteomics coupled transcriptomics reveals lipopolysaccharide inhibiting peroxisome proliferator-activated receptors signalling pathway to reduce lipid droplets accumulation in mouse liver. Proteomics, 23(19):e2300043(2023) [pubmed] |
Keyword List
| submitter keyword: Quantitative proteomics, Peroxisome proliferator-activated receptors signalling pathway, lipid droplet, lipopolysaccharide |
Contact List
| Jiangbei Yuan | |
|---|---|
| contact affiliation | Army Medical University |
| contact email | yuanjiangbei@163.com |
| lab head | |
| Jiangbei Yuan | |
| contact affiliation | Army Medical University |
| contact email | yuanjiangbei@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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