PXD039693 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | RyR1 protein decrease induces ER stress and plays a major role in myopathies |
Description | It has been recently shown that RyR1 protein decrease induces in vivo most features of myopathy. However, the mechanisms underlying these disorders are not clarified. In the present study, using bioinformatics, OMICS, molecular biology and imaging system, we decipher how decreased RyR1 content in muscle cell leads to the development of muscle disease. Our results show that RyR1 depletion induces mitochondrial aggregation and dysfunction by defects in mitophagy and endoplasmic reticulum (ER)-mitochondrial tethering and alters lipid homeostasis. Those alterations are associated with the ER stress. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:27:20.131.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Manfredo Quadroni |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-01-26 11:09:55 | ID requested | |
1 | 2024-01-26 10:27:35 | announced | |
⏵ 2 | 2024-10-22 06:27:20 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1002/jcsm.13349; |
Vidal J, Fernandez EA, Wohlwend M, Laurila PP, Lopez-Mejia A, Ochala J, Lobrinus AJ, Kayser B, Lopez-Mejia IC, Place N, Zanou N, Ryanodine receptor type 1 content decrease-induced endoplasmic reticulum stress is a hallmark of myopathies. J Cachexia Sarcopenia Muscle, 14(6):2882-2897(2023) [pubmed] |
Keyword List
submitter keyword: mitophagy, periliplin2,myopathy, ER stress, sphingolipids, ryanodine receptor |
Contact List
Nadege Zanou |
contact affiliation | Institute of Sports Sciences, Faculty of Biology and Medicine, University of Lausanne |
contact email | nadege.zanou@unil.ch |
lab head | |
Manfredo Quadroni |
contact affiliation | University of Lausanne |
contact email | manfredo.quadroni@unil.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD039693
- Label: PRIDE project
- Name: RyR1 protein decrease induces ER stress and plays a major role in myopathies