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PXD039693

PXD039693 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRyR1 protein decrease induces ER stress and plays a major role in myopathies
DescriptionIt has been recently shown that RyR1 protein decrease induces in vivo most features of myopathy. However, the mechanisms underlying these disorders are not clarified. In the present study, using bioinformatics, OMICS, molecular biology and imaging system, we decipher how decreased RyR1 content in muscle cell leads to the development of muscle disease. Our results show that RyR1 depletion induces mitochondrial aggregation and dysfunction by defects in mitophagy and endoplasmic reticulum (ER)-mitochondrial tethering and alters lipid homeostasis. Those alterations are associated with the ER stress.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:27:20.131.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterManfredo Quadroni
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-01-26 11:09:55ID requested
12024-01-26 10:27:35announced
22024-10-22 06:27:20announced2024-10-22: Updated project metadata.
Publication List
10.1002/jcsm.13349;
Vidal J, Fernandez EA, Wohlwend M, Laurila PP, Lopez-Mejia A, Ochala J, Lobrinus AJ, Kayser B, Lopez-Mejia IC, Place N, Zanou N, Ryanodine receptor type 1 content decrease-induced endoplasmic reticulum stress is a hallmark of myopathies. J Cachexia Sarcopenia Muscle, 14(6):2882-2897(2023) [pubmed]
Keyword List
submitter keyword: mitophagy, periliplin2,myopathy, ER stress, sphingolipids, ryanodine receptor
Contact List
Nadege Zanou
contact affiliationInstitute of Sports Sciences, Faculty of Biology and Medicine, University of Lausanne
contact emailnadege.zanou@unil.ch
lab head
Manfredo Quadroni
contact affiliationUniversity of Lausanne
contact emailmanfredo.quadroni@unil.ch
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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