PXD039693

PXD039693 is an original dataset announced via ProteomeXchange.

Title	RyR1 protein decrease induces ER stress and plays a major role in myopathies
Description	It has been recently shown that RyR1 protein decrease induces in vivo most features of myopathy. However, the mechanisms underlying these disorders are not clarified. In the present study, using bioinformatics, OMICS, molecular biology and imaging system, we decipher how decreased RyR1 content in muscle cell leads to the development of muscle disease. Our results show that RyR1 depletion induces mitochondrial aggregation and dysfunction by defects in mitophagy and endoplasmic reticulum (ER)-mitochondrial tethering and alters lipid homeostasis. Those alterations are associated with the ER stress.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:27:20.131.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manfredo Quadroni
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-26 11:09:55	ID requested
1	2024-01-26 10:27:35	announced
⏵ 2	2024-10-22 06:27:20	announced	2024-10-22: Updated project metadata.

10.1002/jcsm.13349;

Vidal J, Fernandez EA, Wohlwend M, Laurila PP, Lopez-Mejia A, Ochala J, Lobrinus AJ, Kayser B, Lopez-Mejia IC, Place N, Zanou N, Ryanodine receptor type 1 content decrease-induced endoplasmic reticulum stress is a hallmark of myopathies. J Cachexia Sarcopenia Muscle, 14(6):2882-2897(2023) [pubmed]

submitter keyword: mitophagy, periliplin2,myopathy, ER stress, sphingolipids, ryanodine receptor

Nadege Zanou
contact affiliation	Institute of Sports Sciences, Faculty of Biology and Medicine, University of Lausanne
contact email	nadege.zanou@unil.ch
lab head
Manfredo Quadroni
contact affiliation	University of Lausanne
contact email	manfredo.quadroni@unil.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD039693

PRIDE project URI

• PRIDE
  1. PXD039693
     1. Label: PRIDE project
     2. Name: RyR1 protein decrease induces ER stress and plays a major role in myopathies