PXD039692

PXD039692 is an original dataset announced via ProteomeXchange.

Title	Adaptive resistance to MEK and PI3K inhibition in pancreatic cancer cells
Description	Pancreatic cancer is one of the most lethal cancers. Preclinical studies have shown adaptive resistance to Raf/MEK/ERK and PI3K/Akt pathway inhibition. We identify common protein expression alterations associated with adaptive resistance to MEK and PI3K kinase inhibition in KRas-mutant pancreatic cancer cells.
HostingRepository	PRIDE
AnnounceDate	2025-03-10
AnnouncementXML	Submission_2025-03-10_15:00:33.786.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juan Francisco Martinez-Aguilar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-26 11:09:31	ID requested
⏵ 1	2025-03-10 15:00:34	announced

10.1002/PMIC.202300041;

submitter keyword: PI3K inhibition, proteomics, adaptive resistance, MEK inhibition, resistance,Pancreatic cancer

Juan F
contact affiliation	National Autonomous University of Mexico. Mexico City
contact email	jmartinez@cic.unam.mx
lab head
Juan Francisco Martinez-Aguilar
contact affiliation	Universidad Nacional Autonoma de Mexico
contact email	jmartinez@cic.unam.mx
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD039692

PRIDE project URI

• PRIDE
  1. PXD039692
     1. Label: PRIDE project
     2. Name: Adaptive resistance to MEK and PI3K inhibition in pancreatic cancer cells