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PXD039614

PXD039614 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAfter virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism
DescriptionCD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is known to play an important role in host defense and immunopathology, its impact on naïve CD8 T cells remains underappreciated. Here we report that exposure to reovirus, both in vitro or in vivo, promotes bystander activation of naïve CD8 T cells within 24 hours and that this distinct subtype of CD8 T cell displays an innate, antiviral, type I interferon sensitized signature. The induction of bystander naïve CD8 T cells is STAT1 dependent and regulated through nicotinamide phosphoribosyl transferase (NAMPT)-mediated enzymatic actions within NAD+ salvage metabolic biosynthesis. These findings identify a novel aspect of CD8 T cell activation following virus infection with implications for human health and physiology.
HostingRepositoryPRIDE
AnnounceDate2023-01-30
AnnouncementXMLSubmission_2023-01-30_06:59:32.280.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD039614
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterVishnupriyanKumar
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-01-23 07:35:22ID requested
12023-01-30 06:59:32announced
Publication List
10.6019/PXD039614;
Keyword List
submitter keyword: T cell,Mouse, Reovirus
Contact List
ShashiGujar
contact affiliationDept of Pathology, Dalhousie University
contact emailshashi.gujar@dal.ca
lab head
VishnupriyanKumar
contact affiliationDalhousie University
contact emailvishnu.priyan@dal.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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