PXD039614 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism |
Description | CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is known to play an important role in host defense and immunopathology, its impact on naïve CD8 T cells remains underappreciated. Here we report that exposure to reovirus, both in vitro or in vivo, promotes bystander activation of naïve CD8 T cells within 24 hours and that this distinct subtype of CD8 T cell displays an innate, antiviral, type I interferon sensitized signature. The induction of bystander naïve CD8 T cells is STAT1 dependent and regulated through nicotinamide phosphoribosyl transferase (NAMPT)-mediated enzymatic actions within NAD+ salvage metabolic biosynthesis. These findings identify a novel aspect of CD8 T cell activation following virus infection with implications for human health and physiology. |
HostingRepository | PRIDE |
AnnounceDate | 2023-01-30 |
AnnouncementXML | Submission_2023-01-30_06:59:32.280.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD039614 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | VishnupriyanKumar |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-01-23 07:35:22 | ID requested | |
⏵ 1 | 2023-01-30 06:59:32 | announced | |
Publication List
Keyword List
submitter keyword: T cell,Mouse, Reovirus |
Contact List
ShashiGujar |
contact affiliation | Dept of Pathology, Dalhousie University |
contact email | shashi.gujar@dal.ca |
lab head | |
VishnupriyanKumar |
contact affiliation | Dalhousie University |
contact email | vishnu.priyan@dal.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD039614
- Label: PRIDE project
- Name: After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism