PXD039605

PXD039605 is an original dataset announced via ProteomeXchange.

Title	Hypolipidemic effects of beetroot juice in SHR-CRP and HHTg rat models of metabolic syndrome: Analysis of hepatic proteome.
Description	Recently, red beetroot has attracted attention as a health promoting functional food. Studies showed that beetroot administration can reduce blood pressure and ameliorate parameters of glucose and lipid metabolism, however, mechanisms underlying these beneficial effects of beetroot are not fully understood. In the current study, we analyzed effects of beetroot on parameters of glucose and lipid metabolism in two models of metabolic syndrome, (i) transgenic spontaneously hypertensive rats expressing human C-reactive protein (SHR-CRP rats), and (ii) hereditary hypertriglyceridemic (HHTg) rats. Treatment with beetroot juice for 4 weeks was in both models associated with amelioration of oxidative stress, reduced circulating lipids, smaller visceral fat depots, and lower ectopic fat accumulation in the liver, compared to their respective untreated controls. On the other hand, beetroot treatment had no significant effects on sensitivity of muscle and adipose tissue to insulin action in both models. Analyses of hepatic proteome revealed significantly deregulated proteins involved in glycerophospholipid metabolism, mTOR signalling, inflammation, and cytoskeleton rearrangement.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:43:50.377.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marek Vrbacky
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	methylthiolated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-23 03:50:18	ID requested
1	2023-03-11 11:04:31	announced
⏵ 2	2023-11-14 08:43:58	announced	2023-11-14: Updated project metadata.

Š, ilhav, ý J, Mlejnek P, Š, im, á, kov, á M, Mal, í, nsk, á H, Markov, á I, H, ü, ttl M, Mikl, á, nkov, á D, Kazdov, á L, Vrback, ý M, Pecinov, á A, Mr, á, č, ek T, Pravenec M, Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome. Metabolites, 13(2):(2023) [pubmed]

submitter keyword: mTOR signaling,spontaneously hypertensive rat, lipids, glycerophospholipid metabolism, beetroot, hereditary hypertriglyceridemic rat

Michal Pravenec
contact affiliation	Institute of Physiology of the Czech Academy of Sciences Laboratory of Developmental Cardiology
contact email	michal.pravenec@fgu.cas.cz
lab head
Marek Vrbacky
contact affiliation	Czech Academy of Sciences
contact email	proteom.krc@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD039605
     1. Label: PRIDE project
     2. Name: Hypolipidemic effects of beetroot juice in SHR-CRP and HHTg rat models of metabolic syndrome: Analysis of hepatic proteome.