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PXD039598
PXD039598 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Metaproteomic analysis of nasopharyngeal swab samples to identify microbial peptides and potential co-infection status in COVID-19 patients |
| Description | Respiratory infections disrupt the microbiota in the upper respiratory tract (URT), putting patients at a risk for subsequent infections. During the pandemic, cases of COVID-19 were aggravated by secondary infections because of impaired immunity and medical interventions, which was clearly evident in the second wave of COVID-19 in India. The potential dangers and clinical difficulties of bacterial and fungal secondary infections in COVID-19 patients necessitate microbial exploration of the URT. In this regard, mass spectrometry (MS)-based proteome data of nasopharyngeal swab samples from COVID-19 patients was used to investigate the metaproteome. The MS datasets were searched against a comprehensive protein sequence database of common URT pathogens using multiple search platforms (MaxQuant, MSFragger, and Search GUI/PeptideShaker). Using parallel reaction monitoring (PRM), we validated a few identified microbial peptides in clinical nasopharyngeal swab samples. |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2025-11-01 |
| AnnouncementXML | Submission_2025-11-01_09:38:18.374.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | supported by repository but incomplete data and/or metadata |
| PrimarySubmitter | Dhanush Borishetty |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl; Label:13C(6)15N(2) |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-01-22 08:39:39 | ID requested | |
| ⏵ 1 | 2025-11-01 09:38:19 | announced |
Publication List
| Bihani S, Gupta A, Mehta S, Rajczewski AT, Johnson J, Borishetty D, Griffin TJ, Srivastava S, Jagtap PD, Metaproteomic Analysis of Nasopharyngeal Swab Samples to Identify Microbial Peptides in COVID-19 Patients. J Proteome Res, 22(8):2608-2619(2023) [pubmed] |
Keyword List
| submitter keyword: Clinical Metaproteomics, COVID-19, Nasopharyngeal Swab |
Contact List
| Sanjeeva Srivastava | |
|---|---|
| contact affiliation | Department of Bioscience and Bioengineering, Indian Institute of Technology, Bombay, India |
| contact email | sanjeeva@iitb.ac.in |
| lab head | |
| Dhanush Borishetty | |
| contact affiliation | Department of Bioscience and Bioengineering, Indian Institute of Technology, Bombay, India |
| contact email | 213300001@iitb.ac.in |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
