PXD039591

PXD039591 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	TGF-β signaling activation modulates the biology of tumor-derived extracellular cellular vesicles
Description	Tumor-derived extracellular vesicles (EVs) have been associated with cancer progression and metastasis due to the transfer of bioactive molecules in between the tumor microenvironment. Although Transforming Growth Factor-β (TGF-β) signaling associated molecules have been implicated as cargo of EVs, the role of TGF-β pathway on EV’s biology to promote tumorigenesis is poorly understood. Hence, we aimed to describe the impact of TGF-β signaling on biogenesis and functional transfer of cargo from tumor-derived EVs induced by TGF-β (EV+TGF-β1). To this end, EV-fractions enriched in CD81 or Cholerae toxin B chain (CTB) were isolated from the vesicular secretome fraction (VSF) of human breast cancer and lung adenocarcinoma cells and further characterized.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:29:02.989.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	José Eduardo Araújo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-20 06:12:18	ID requested
⏵ 1	2025-05-06 09:29:03	announced

Publication List

10.1186/s13046-025-03291-0;
Rodrigues-Junior DM, Tsirigoti C, Psatha K, Kletsas D, Aivaliotis M, Heldin CH, Moustakas A, induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles. J Exp Clin Cancer Res, 44(1):42(2025) [pubmed]

10.1186/s13046-025-03291-0;

Rodrigues-Junior DM, Tsirigoti C, Psatha K, Kletsas D, Aivaliotis M, Heldin CH, Moustakas A, induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles. J Exp Clin Cancer Res, 44(1):42(2025) [pubmed]

Keyword List

submitter keyword: Extracellular vesicles (EV), Transforming Growth Factor β (TGF- β), Cancer, Drug resistance, Metastasis

submitter keyword: Extracellular vesicles (EV), Transforming Growth Factor β (TGF- β), Cancer, Drug resistance, Metastasis

Contact List

Janne Lehtiö
contact affiliation	Oncology Pathology, Karolinska Institutet, and Scilifelab, Stockholm, Sweden
contact email	janne.lehtio@ki.se
lab head
José Eduardo Araújo
contact affiliation	Clinical Proteomics Mass Spectrometry, SciLifeLab, Karolinska Institutet
contact email	jose-eduardo.araujo@scilifelab.se
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD039591
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD039591

PRIDE project URI

Repository Record List

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