PXD039562
PXD039562 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Systemic toxicity of snake venom metalloproteinases: proteomics analyses of kidney injury and blood plasma disturbances in a mouse model |
| Description | Metalloproteinases are abundant in viperid venoms and are implicated in several envenomation effects. Bothrops jararaca venom is reported to induce kidney injury and coagulopathy. HF3 is an extremely hemorrhagic metalloproteinase from B. jararaca venom and participates in the local pathogenesis of envenomation. Here we applied proteomics approaches to evaluate the effects of HF3 in the mouse kidney and blood plasma after 2 h and 6 h of HF3 injection in the thigh muscle. All proteomic analyses were performed using orbitrap-based high-resolution mass spectrometry. For kidney tissue and plasma proteomic analysis, proteins were extracted and submitted to trypsin digestion and peptides were TMT-labeled for relative quantification. For N-terminomic analysis of kidney tissue, a modified Terminal Amine Isotopic Labeling of Substrates (TAILS) protocol was applied, using TMT-tags for free-amine blocking and relative quantification. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-02-29 |
| AnnouncementXML | Submission_2024-02-29_10:18:07.517.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Miguel Cosenza-Contreras |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Carbamidomethyl |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-01-20 01:18:46 | ID requested | |
| ⏵ 1 | 2024-02-29 10:18:07 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: snake venom effect, mouse model, metalloproteinase, HF3, kidney, plasma |
Contact List
| Prof. Oliver Schilling | |
|---|---|
| contact affiliation | Institute for Surgical Pathology, University Medical Center Freiburg |
| contact email | oliver.schilling@mol-med.uni-freiburg.de |
| lab head | |
| Miguel Cosenza-Contreras | |
| contact affiliation | UNIVERSIT�TSKLINIKUM FREIBURG |
| contact email | miguel.de.jesus.cosenza.contreras@uniklinik-freiburg.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v05/MSV000091101/ |
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