PXD039546

PXD039546 is an original dataset announced via ProteomeXchange.

Title	Proteome characterization of germ cell tumor-related somatic-type malignancies for the identification of tissue origin, cisplatin resistance mechanisms, and putative therapeutic options
Description	Germ cell tumors (GCT) can be distinguished into seminoma and non-seminoma. The latter comprises embryonal carcinoma, which can further differentiate into choriocarcinoma, teratoma (TER), and yolk-sac tumors (YST). However, GCT can transform into a somatic-type malignancy (STM), eventually resulting in an unfavorable outcome. This study aimed at enlightening the molecular mechanisms leading to STM formation by comparing them to TER and YST as presumable tissues of origin, thereby paving the way for the identification of novel druggable targets.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_14:42:58.995.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stella Pauls
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-18 16:23:30	ID requested
⏵ 1	2024-01-26 14:42:59	announced

10.1038/s41416-023-02425-5;

Bremmer F, Pongratanakul P, Skowron M, Che Y, Richter A, K, ü, ffer S, Reuter-Jessen K, Bohnenberger H, Pauls S, Kresbach C, Sch, ü, ller U, St, ü, hler K, Str, ö, bel P, Albers P, Nettersheim D, Characterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor-related somatic-type malignancies to identify the tissue-of-origin, mechanisms of therapy resistance, and druggable targets. Br J Cancer, 129(10):1580-1589(2023) [pubmed]

submitter keyword: somatic-type malignancy, yolk-sac tumors,Germ cell tumors, therapy resistance

Kai Stühler
contact affiliation	Molecular proteomics laboratory (MPL), Institut für Molekulare Medizin, Medizinische Fakultät, Heinrich-Heine-Universität, Universitätsstraße 1, D-40225 Düsseldorf
contact email	Kai.stuehler@hhu.de
lab head
Stella Pauls
contact affiliation	Molecular Proteomics Laboratory
contact email	stella.pauls@hhu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD039546

PRIDE project URI

• PRIDE
  1. PXD039546
     1. Label: PRIDE project
     2. Name: Proteome characterization of germ cell tumor-related somatic-type malignancies for the identification of tissue origin, cisplatin resistance mechanisms, and putative therapeutic options