PXD039491

PXD039491 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	PRDX6 as a promoter of cancer malignancy in hepatocarcinoma cell lines targeting GSK3B
Description	This project describes the mechanism by wich PRDX6 affects migration and invasiveness in hepatocarcinoma cells. SNU475 (mesenchymal) hepatocarcinoma cell line knockout for PRDX6 showed a marked increase in ROS and lipid peroxidation, mytochondrial dysfunction, metabolic reprogramming, altered cytoskeleton and activation of upstream regulators MYC, ATF4, HNF4A and HNF4G and inhibition of NRF2 and TP53. All these changes point to a role of PRDX6 in tumor development pointing to it as a candidate for antitumoral therapies.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:56:13.964.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Raquel Requejo-Aguilar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-16 13:53:21	ID requested
1	2023-07-20 11:23:33	announced
2	2023-11-14 09:03:26	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:56:14	announced	2024-10-22: Updated project metadata.

Publication List

10.3390/antiox12061153;
Lagal DJ, L, ó, pez-Grueso MJ, Pedrajas JR, Leto TL, B, á, rcena JA, Requejo-Aguilar R, Padilla CA, Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines. Antioxidants (Basel), 12(6):(2023) [pubmed]

10.3390/antiox12061153;

Lagal DJ, L, ó, pez-Grueso MJ, Pedrajas JR, Leto TL, B, á, rcena JA, Requejo-Aguilar R, Padilla CA, Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines. Antioxidants (Basel), 12(6):(2023) [pubmed]

Keyword List

ProteomeXchange project tag: Liver (B/D-HPP), Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
submitter keyword: lipid peroxidation, GSK3B,Peroxiredoxin 6, ROS, Mitochondrial dysfunction, Cell cycle, Hepatocarcinoma

ProteomeXchange project tag: Liver (B/D-HPP), Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: lipid peroxidation, GSK3B,Peroxiredoxin 6, ROS, Mitochondrial dysfunction, Cell cycle, Hepatocarcinoma

Contact List

Raquel Requejo Aguilar
contact affiliation	Biochemistry and Molecular Biology Department, University of Córdoba (Spain)
contact email	bb2reagr@uco.es
lab head
Raquel Requejo-Aguilar
contact affiliation	Córdoba University
contact email	bb2reagr@uco.es
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD039491
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD039491

PRIDE project URI

Repository Record List

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