PXD039471

PXD039471 is an original dataset announced via ProteomeXchange.

Title	Changes in the proteome of human induced pluripotent stem cells derived endothelial cells with CRISPR/Cas9 induced monoallelic and biallelic mutation of the HNF1A gene
Description	Maturity onset diabetes of the young (MODY) is caused by a mutation in a single gene and leads to diabetes under the age of 25. The mutations in HNF1A gene (leading to HNF1A-MODY) cause about 70% of all MODY cases. It was shown that patients with HNF1A-MODY often develop diabetic microvascular complications, related to endothelial dysfunction, however, it is not clear whether these complications are the result of hyperglycemia or due to the genetic mutation in HNF1A gene. For analysis, monoallelic (MAC) and biallelic (BAC) mutants in the HNF1A gene were used for comparative proteomics to the isogenic control (hiPSCs-EC).
HostingRepository	PRIDE
AnnounceDate	2026-03-01
AnnouncementXML	Submission_2026-03-01_10:38:30.307.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Neli Kachamakova-Trojanowska
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-16 08:16:44	ID requested
⏵ 1	2026-03-01 10:38:30	announced

10.1186/S13073-026-01615-Z;

submitter keyword: Maturity onset diabetes of the young, endothelial cells,HNF1A-MODY, iPSCs-EC

Neli Kachamakova-Trojanowska
contact affiliation	Molecular Mechanisms of Disease Research Group, Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Krakow, Poland
contact email	neli.kachamakova-trojanowska@uj.edu.pl
lab head
Neli Kachamakova-Trojanowska
contact affiliation	Malopolska Centre of Biotechnology, Jagiellonian University
contact email	neli.kachamakova-trojanowska@uj.edu.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD039471

PRIDE project URI

• PRIDE
  1. PXD039471
     1. Label: PRIDE project
     2. Name: Changes in the proteome of human induced pluripotent stem cells derived endothelial cells with CRISPR/Cas9 induced monoallelic and biallelic mutation of the HNF1A gene