PXD039437

PXD039437 is an original dataset announced via ProteomeXchange.

Title	Pivotal role for S-nitrosylation of DNA methyltransferase in epigenetic regulation
Description	DNMTs catalyze the methylation of cytosine with SAM. DNA methylation affects key cellular processes by regulating gene expression, thus serving a variety of physiological and pathophysiological roles. However, the chemical mechanisms of DNA methylation by which its enzymatic activity is regulated have not been fully elucidated. We found that a critical cysteine residue in DNMT is the target of protein S-nitrosylation, leading to the attenuation of DNMT enzymatic activity and consequent aberrant regulation of gene expression during neoplastic cell proliferation. Our results demonstrate that de novo DNA methylation mediated by DNMT3 is regulated by NO, which is involved in tumor formation.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:43:43.159.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akihiro Ito
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-nitrosyl-L-cysteine
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-13 14:29:30	ID requested
1	2023-03-11 10:56:41	announced
⏵ 2	2023-11-14 08:43:44	announced	2023-11-14: Updated project metadata.

Okuda K, Nakahara K, Ito A, Iijima Y, Nomura R, Kumar A, Fujikawa K, Adachi K, Shimada Y, Fujio S, Yamamoto R, Takasugi N, Onuma K, Osaki M, Okada F, Ukegawa T, Takeuchi Y, Yasui N, Yamashita A, Marusawa H, Matsushita Y, Katagiri T, Shibata T, Uchida K, Niu SY, Lang NB, Nakamura T, Zhang KYJ, Lipton SA, Uehara T, Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis. Nat Commun, 14(1):621(2023) [pubmed]

submitter keyword: NO, Cancer,S-nitrosylation, DNA methylation, Epigenetics

Akihiro Ito
contact affiliation	School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Japan
contact email	aito@toyaku.ac.jp
lab head
Akihiro Ito
contact affiliation	School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
contact email	aito@toyaku.ac.jp
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD039437

PRIDE project URI

• PRIDE
  1. PXD039437
     1. Label: PRIDE project
     2. Name: Pivotal role for S-nitrosylation of DNA methyltransferase in epigenetic regulation