PXD039424

PXD039424 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of the mandibular glands from the Chinese crocodile lizard, Shinisaurus crocodilurus – another venomous lizard?
Description	Based on its phylogenetic relationship to monitor lizards (Varanidae), Gila monsters (Heloderma spp.), and the earless monitor Lanthanotus borneesis, the Chinese crocodile lizard, Shinisaurus crocodilurus, has been assigned to the Toxicofera clade, which comprises venomous reptiles. However, no data about composition and biological activities of its oral secretion have been reported. In the present study, a proteomic analysis of the mandibular gland of S. crocodilurus and, for comparison, of the herbivorous Solomon Island skink Corucia zebrata, was performed. Scanning electron microscopy (SEM) of the teeth from S. crocodilurus revealed a sharp ridge on the anterior surface, but no grooves, whereas those of C. zebrata possess a flattened crown with a pointed cusp. Proteomic analysis of their gland extracts provided no evidence of venom-derived peptides or proteins, strongly supporting the non-venomous character of these lizards.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:43:42.835.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Davinia Pla
SpeciesList	scientific name: Corucia; NCBI TaxID: 96730; scientific name: Shinisaurus crocodilurus; NCBI TaxID: 52224;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-13 07:25:28	ID requested
1	2023-03-11 10:56:25	announced
⏵ 2	2023-11-14 08:43:45	announced	2023-11-14: Updated project metadata.

Calvete JJ, Lomonte B, Lorente C, Pla D, Zollweg M, Mebs D, Proteomic analysis of the mandibular glands from the Chinese crocodile lizard, Shinisaurus crocodilurus - Another venomous lizard? Toxicon, 225():107050(2023) [pubmed]

submitter keyword: Chinese crocodile lizard

Shinisaurus crocodilurus

Solomon Island skink

Corucia zebrata

mandibular gland

proteomic analysis.

Juan José Calvete Chornet
contact affiliation	Evolutionary and translational venomics Lab, Instituto de Biomedicina de Valencia, CSIC
contact email	jcalvete@ibv.csic.es
lab head
Davinia Pla
contact affiliation	CSIC
contact email	dpla@ibv.csic.es
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD039424
     1. Label: PRIDE project
     2. Name: Proteomic analysis of the mandibular glands from the Chinese crocodile lizard, Shinisaurus crocodilurus – another venomous lizard?