Update publication information. The Polygonatum cyrtonema Hua rhizomes (Rhizoma Polygonati, RP) are consumed for health benefits. The main source of the RP is wild P. cyrtonema populations in the Hunan province of China. However, the soil Cadmium (Cd) content in Huanan is increasing, thus increasing the risks of Cd accumulation in RP and ending up in the human food chain. We subjected different levels of Cd stress to study the protein regulation mechanism under cadmium stress of P. cyrtonema.