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PXD039344

PXD039344 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIntegrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phosphoproteomics, and metabolomics
DescriptionDiabetic peripheral neuropathy (DPN) is characterized by spontaneous pain in the extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However, there remains a lack of safe, effective analgesics to control this chronic painful condition. Dorsal root ganglia (DRG) contain soma of sensory neurons and modulate sensory signal transduction into the central nervous system. In this study, we aimed to gain a deeper understanding of changes in molecular pathways in the DRG of DPN patients with chronic pain. We recently reported transcriptomic changes in the DRG with DPN. Here, we expand upon those results with integrated metabolomic, proteomic, and phosphoproteomic analyses to compare the molecular profiles of DRG from DPN donors and DRG from control donors without diabetes or chronic pain. Our analyses identified decreases of select amino acids and phospholipid metabolites in the DRG from DPN donors, which are important for cellular maintenance. Additionally, our analyses revealed changes suggestive of extracellular matrix (ECM) remodeling and altered mRNA processing. These results reveal new insights into changes in the molecular profiles associated with DPN.
HostingRepositoryMassIVE
AnnounceDate2023-01-10
AnnouncementXMLSubmission_2023-01-10_05:26:44.058.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYan Wang
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListPhospho
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-01-09 14:14:33ID requested
12023-01-10 05:26:44announced
Publication List
Doty M, Yun S, Wang Y, Hu M, Cassidy M, Hall B, Kulkarni AB, Integrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phospho-proteomics, and metabolomics. Sci Rep, 12(1):17012(2022) [pubmed]
Keyword List
submitter keyword: Diabetic peripheral neuropathy, Dorsal root ganglia, proteomics, phosphoproteomics
Contact List
Yan Wang
contact affiliationNIH/NIDCR
contact emailwangyan2@nih.gov
lab head
Yan Wang
contact affiliationNIH
contact emailWangyan2@nih.gov
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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