PXD039285

PXD039285 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analaysis of colorectal cancer
Description	Colorectal cancer (CRC) remains among the topmost malignancy across the globe. It stands to be the leading cause of cancer mortality worldwide. It is the second most common cancer diagnosed in women and the third most in men that accounts for approximately 10% of cancers diagnosed annually. It will be worthwhile to identify and measure the dysregulated protein marker in order to comprehend illness pathobiology and improve disease diagnosis and therapy. This study utilizes high throughput quantitative tissue proteomics approach to study the dysregulation. This work aimed at examining proteomic dysregulation in human CRC tissue samples as compared to matched peritumoral tissue from a diverse patient population of Indian origin using Tandem Mass Tag (TMT) to identify potential biomarkers. The altered proteins from the study were further taken for biological pathway analysis to decipher the insights of disease biology. This study is one of the first comprehensive proteome-wide investigations of Indian CRC patients detecting potentially altered protein candidates in the disease development and metastasis which can be used as a potent biomarker.
HostingRepository	PRIDE
AnnounceDate	2025-10-13
AnnouncementXML	Submission_2025-10-13_09:04:38.754.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Abhilash Barpanda
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-05 08:36:20	ID requested
⏵ 1	2025-10-13 09:04:39	announced

10.1089/omi.2022.0169;

Barpanda A, Halder A, Dhote A, Parihari S, Kantharia C, Srivastava S, Colon Adenocarcinoma Quantitative Proteomics Reveals Dysregulation in Key Cancer Signaling Pathways and a Candidate Protein Marker Panel. OMICS, 27(2):75-85(2023) [pubmed]

submitter keyword: Orbitrap fusion, TMT, tumor tissue,Colorectal cancer, LC-MS/MS

Dr. Sanjeeva Srivastava
contact affiliation	Professor and Lab head, IIT Bombay
contact email	sanjeeva@iitb.ac.in
lab head
Abhilash Barpanda
contact affiliation	IIT Bombay
contact email	avilash94@iitb.ac.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD039285

PRIDE project URI

• PRIDE
  1. PXD039285
     1. Label: PRIDE project
     2. Name: Quantitative proteomic analaysis of colorectal cancer