PXD039273

PXD039273 is an original dataset announced via ProteomeXchange.

Title	Detection of pancreatic ductal adenocarcinoma-associated proteins in serum
Description	Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types, partly because it is frequently identified at an advanced stage, when surgery is no longer feasible. Therefore, early detection using minimally invasive methods such as blood tests may improve outcomes. However, studies to discover molecular signatures for the early detection of PDAC using blood tests have only been marginally successful. In the current study, a quantitative glycoproteomic approach via data-independent acquisition mass spectrometry (DIA-MS) was utilized to detect glycoproteins in 29 patient-matched PDAC tissues and sera. Total of 892 glycopeptides originated from 141 glycoproteins had PDAC associated changes beyond normal variation. We further evaluated the specificity of these serum detectable glycoproteins by comparing their abundance in 53 independent PDAC patient sera and 65 cancer-free controls. The PDAC tissue-associated glycoproteins we have identified represent an inventory of serum detectable PDAC glycoproteins as candidate biomarkers that can be potentially used for the detection of PDAC using blood tests.
HostingRepository	PRIDE
AnnounceDate	2023-12-20
AnnouncementXML	Submission_2023-12-19_19:14:50.115.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yingwei HU
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	deamidated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-05 02:19:20	ID requested
⏵ 1	2023-12-19 19:14:50	announced

10.1016/J.MCPRO.2023.100687;

ProteomeXchange project tag: CPTAC Consortium

submitter keyword: Serum,Pancreatic ductal adenocarcinoma, Glycoproteomics, Mass spectrometry

Hui Zhang
contact affiliation	Johns Hopkins University
contact email	huizhang@jhu.edu
lab head
Yingwei HU
contact affiliation	Johns Hopkins University
contact email	yhu39@jhmi.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD039273

PRIDE project URI

• PRIDE
  1. PXD039273
     1. Label: PRIDE project
     2. Name: Detection of pancreatic ductal adenocarcinoma-associated proteins in serum