PXD039234

PXD039234 is an original dataset announced via ProteomeXchange.

Title	Ciona savignyi embryos 4D Label-free Quantitative Phosphoproteomics
Description	Formation of tubular system is crucial for embryogenesis and adult metabolism. However，the underlying mechanisms remain largely unclear. We demonstrated that a dual specificity tyrosine-phosphorylation-regulated kinase 1 (DYRK1), the protein kinase, which was upregulated during lumenogenesis and required for ascidian notochord extracellular lumen expansion. Here, we applied 4D Label-free Quantitative Phosphoproteomics and aimed to find out the potential substrates (phosphoproteins) that were regulated by DYRK1during ascidian Ciona notochord lumen expansion.
HostingRepository	iProX
AnnounceDate	2023-01-04
AnnouncementXML	Submission_2023-03-13_00:13:05.979.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiuke Ouyang
SpeciesList	scientific name: Ciona savignyi; NCBI TaxID: 51511;
ModificationList	phosphorylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-04 03:25:00	ID requested
1	2023-01-04 03:25:12	announced
⏵ 2	2023-03-13 00:13:06	announced	2023-03-13: Update publication information.

Ouyang X, Wu B, Yu H, Dong B, DYRK1-mediated phosphorylation of endocytic components is required for extracellular lumen expansion in ascidian notochord. Biol Res, 56(1):10(2023) [pubmed]

submitter keyword: ascidian embryos，lumenogenesis，DYRK1，AZ191，phosphoproteomics

Bo Dong
contact affiliation	Ocean University of China
contact email	bodong@ouc.edu.cn
lab head
Xiuke Ouyang
contact affiliation	Ocean University of China
contact email	ouyangxiuke@stu.ouc.edu.cn
dataset submitter

iProX dataset URI