PXD039204

PXD039204 is an original dataset announced via ProteomeXchange.

Title	Comparative quantitative proteomics in renal cell carcinoma to identify the novel progression factors
Description	Over 90% of kidney malignancies are renal cell carcinomas (RCC), which are tumors arising from the renal epithelium. Clear cell RCC (ccRCC) is the most frequent histological subtype and the cause of the majority of kidney cancer-related fatalities. Because of its low 5-year survival rate, poor prognosis, and poor treatment response to chemotherapy and radiation, metastatic RCC (mRCC) is considered a severe condition among kidney cancers. Although different therapies have been tried for mRCC, new therapeutic targets are still needed to overcome the disease. Currently, genomics and transcriptomics studies are being conducted in order to uncover specific genes associated with mRCC. In addition, we were able to apply mass spectrometry-based comparative proteomics, which has become more widely available. Following we performed research to identify the novel progression factors in mRCC based on proteomics approaches, more information about the progression to mRCC using quantitative profiling was identified. In this study, we selected 239 differentially expressed proteins among the 2,905 quantified proteins. We finally chose the 6 target proteins to perform next research.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_07:16:04.082.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ann-Yae Na
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-03 00:55:06	ID requested
⏵ 1	2024-01-26 07:16:05	announced

Park J, Lee EH, Sim H, Na AY, Choi SY, Chung JW, Ha YS, Kwon TG, Lee S, Lee JN, Using Comparative Proteomics to Identify Protein Signatures in Clear Cell Renal Cell Carcinoma. Cancer Genomics Proteomics, 20(6):592-601(2023) [pubmed]

10.21873/cgp.20408;

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project, Bioinformatics Infrastructure for Life Sciences (BILS) network (Sweden)

submitter keyword: : clear cell renal carcinoma

metastasis

comparative proteomics

prognostic marker

serpine A3

Sangkyu Lee
contact affiliation	Kyungpook national university
contact email	pharm239@gmail.com
lab head
Ann-Yae Na
contact affiliation	kyungpook national university
contact email	cpblady@hanmail.net
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD039204

PRIDE project URI

• PRIDE
  1. PXD039204
     1. Label: PRIDE project
     2. Name: Comparative quantitative proteomics in renal cell carcinoma to identify the novel progression factors