PXD039184

PXD039184 is an original dataset announced via ProteomeXchange.

Title	E3 ligase AMFR regulates ARL6IP1 Ubiquitination in cells
Description	ER-resident membrane-shaping proteins with central reticulon homology domains (RHDs) have been associated with neurodegenerative disorders such as ARL6IP1 and FAM134B.Mutations in ARL6IP1 cause SPG61, a neurodegenerative disorder characterized by progressive leg spasticity (hereditary spastic paraplegia/HSP) in combination with loss of sensory and pain perception, thus reproducing typical symptoms of HSAN {Kurth, 2009 #8;Novarino, 2014 #28;Nizon, 2018 #162}.Our objetive was to analyse FAM134B-ARL6IP1 protein protein interactionS to underlying mechanisms, required for effective ER-remodelling and ER-phagy.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:49:00.131.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Adriana Covarrubias-Pinto
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-02 19:13:14	ID requested
1	2023-06-19 06:48:08	announced
2	2023-11-14 09:01:35	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:49:00	announced	2024-10-22: Updated project metadata.

10.1038/s41586-023-06090-9;

Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, Gonz, á, lez A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L, Hoffmann ME, Katona I, Koch N, Weis J, Kurth I, Gleeson JG, Reggiori F, Hummer G, Kessels MM, Qualmann B, Mari M, Diki, ć I, H, ü, bner CA, Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy. Nature, 618(7964):402-410(2023) [pubmed]

submitter keyword: AMFR, ARL6IP1 ubiquitination

Ivan Dikic
contact affiliation	Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
contact email	dikic@biochem2.uni-frankfurt.de
lab head
Adriana Covarrubias-Pinto
contact affiliation	Goethe University
contact email	CovarrubiasPinto@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD039184

PRIDE project URI

• PRIDE
  1. PXD039184
     1. Label: PRIDE project
     2. Name: E3 ligase AMFR regulates ARL6IP1 Ubiquitination in cells