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PXD039184

PXD039184 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleE3 ligase AMFR regulates ARL6IP1 Ubiquitination in cells
DescriptionER-resident membrane-shaping proteins with central reticulon homology domains (RHDs) have been associated with neurodegenerative disorders such as ARL6IP1 and FAM134B.Mutations in ARL6IP1 cause SPG61, a neurodegenerative disorder characterized by progressive leg spasticity (hereditary spastic paraplegia/HSP) in combination with loss of sensory and pain perception, thus reproducing typical symptoms of HSAN {Kurth, 2009 #8;Novarino, 2014 #28;Nizon, 2018 #162}.Our objetive was to analyse FAM134B-ARL6IP1 protein protein interactionS to underlying mechanisms, required for effective ER-remodelling and ER-phagy.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_09:01:25.485.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAdriana Covarrubias-Pinto
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-01-02 19:13:14ID requested
12023-06-19 06:48:08announced
22023-11-14 09:01:35announced2023-11-14: Updated project metadata.
Publication List
Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, Gonz, á, lez A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L, Hoffmann ME, Katona I, Koch N, Weis J, Kurth I, Gleeson JG, Reggiori F, Hummer G, Kessels MM, Qualmann B, Mari M, Diki, ć I, H, ü, bner CA, Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy. Nature, 618(7964):402-410(2023) [pubmed]
Keyword List
submitter keyword: AMFR, ARL6IP1 ubiquitination
Contact List
Ivan Dikic
contact affiliationInstitute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
contact emaildikic@biochem2.uni-frankfurt.de
lab head
Adriana Covarrubias-Pinto
contact affiliationGoethe University
contact emailCovarrubiasPinto@med.uni-frankfurt.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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