PXD039169

PXD039169 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Integrated proteomics and transcriptomics profiling reveals distinct aspects of kidney stone related genes in calculi rats
Description	We conducted a calculi rat model, applied for an integrated proteomic and transcriptomic analysis to characterize the distinct gene expression profiles in calculi oxalate stone formation and its related kidney injury. Six distinct gene clusters were identified according to the consistency of transcriptome and proteome. Gene Ontology and KEGG pathway enrichment was performed to analyze the functions of each sub-group differentially expressed genes. Results showed that the calculi rat kidney was increased expression of injured & apoptotic markers and immune-molecules, and decreased expression of solute carriers & transporters and many metabolic related factors. The present proteotranscriptomic study provided a data resource and new insights for better understanding of the pathogenesis of nephrolithiasis, will hopefully facilitate the future development of new strategies for the recurrence prevention and treatment in patients with kidney stone disease.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:47:13.118.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhu Wang
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-02 19:07:35	ID requested
1	2023-05-10 13:55:21	announced
⏵ 2	2023-11-14 08:47:15	announced	2023-11-14: Updated project metadata.

Publication List

Zhu W, Qiong D, Yanli G, Min L, Ying Z, Qiyi H, Shenping Z, Xisheng W, Hui L, Proteomics and transcriptomics profiling reveals distinct aspects of kidney stone related genes in calculi rats. BMC Genomics, 24(1):127(2023) [pubmed]

Zhu W, Qiong D, Yanli G, Min L, Ying Z, Qiyi H, Shenping Z, Xisheng W, Hui L, Proteomics and transcriptomics profiling reveals distinct aspects of kidney stone related genes in calculi rats. BMC Genomics, 24(1):127(2023) [pubmed]

Keyword List

submitter keyword: Calcium oxalate
Kidney stone
Proteomics
Transcriptomics
Urolithiasis

submitter keyword: Calcium oxalate

Kidney stone

Proteomics

Transcriptomics

Urolithiasis

Contact List

Zhu WANG
contact affiliation	Department of Urology, People’s Hospital of Longhua Shenzhen, Southern Medical University, Shenzhen, Guangdong 518109, P.R. China
contact email	wangzhu@smu.edu.cn
lab head
Zhu Wang
contact affiliation	Southern Medical University
contact email	wangzhu@smu.edu.cn
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD039169

PRIDE project URI

Repository Record List

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