PXD039139

PXD039139 is an original dataset announced via ProteomeXchange.

Title	Fangs in the ghats: preclinical insights into the medical importance of endemic pit vipers from the Western Ghats
Description	The socioeconomic burden of snakebite in India is largely attributed to the ‘big four’ snakes, completely neglecting the considerable impact of envenoming by many other snake species. Bites from the so-called ‘neglected many’ are often treated with a polyvalent antivenom that is manufactured against the ‘big four’ snakes - a strategy that has been widely documented to fail. Yet, specific antivenoms are not commercially manufactured against these snakes. While the medical importance of various species of cobras, saw-scaled vipers, and kraits is very well-known, the clinical impact of pit vipers from the rainforests of the Western Ghats, northeastern India, and Andaman and Nicobar islands has remained elusive. Amongst the 90+ species of snakes found in the Western Ghats, the hump-nosed (Hypnale hypnale), Malabar (Craspedocephalus malabaricus) and bamboo (Craspedocephalus gramineus) pit vipers can potentially inflict clinically severe envenoming in humans. To evaluate the severity of toxicity inflicted by these snakes, we characterised their venom composition, biochemical and pharmacological activities, and toxicity- and morbidity-inducing potentials. Our findings highlight the therapeutic inadequacies of the generic Indian and Hypnale-specific Sri Lankan polyvalent antivenoms in neutralising morbidity and mortality resulting from pit viper envenomings and underscore the need for a regional antivenom therapy in India.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:56:04.826.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kartik Sunagar
SpeciesList	scientific name: Trimeresurus malabaricus; NCBI TaxID: 109784; scientific name: Hypnale hypnale; NCBI TaxID: 44720; scientific name: Trimeresurus gramineus; NCBI TaxID: 8767;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-02 01:24:05	ID requested
1	2023-07-20 11:19:19	announced
2	2023-11-14 09:03:23	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:56:05	announced	2024-10-22: Updated project metadata.

10.3390/ijms24119516;

Khochare S, Senji Laxme RR, Jaikumar P, Kaur N, Attarde S, Martin G, Sunagar K, Fangs in the Ghats: Preclinical Insights into the Medical Importance of Pit Vipers from the Western Ghats. Int J Mol Sci, 24(11):(2023) [pubmed]

submitter keyword: Craspedocephalus gramineus, preclinical research, Craspedocephalus malabaricus,Hypnale hypnale

Dr. Kartik Sunagar
contact affiliation	Assistant Professor, Evolutionary Venomics Lab, Center for Ecological Sciences, Indian Institute of Science, Bangalore, India
contact email	ksunagar@iisc.ac.in
lab head
Kartik Sunagar
contact affiliation	Assistant Professor, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India.
contact email	ksunagar@iisc.ac.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD039139

PRIDE project URI

• PRIDE
  1. PXD039139
     1. Label: PRIDE project
     2. Name: Fangs in the ghats: preclinical insights into the medical importance of endemic pit vipers from the Western Ghats