PXD039060

PXD039060 is an original dataset announced via ProteomeXchange.

Title	Pathogenic Bacteria Exploit Transferrin Receptor Transcytosis to Penetrate the Blood‒Brain Barrier
Description	In this study, we present evidence showing that the infection with the major meningitis-causing bacteria, NMEC, GBS and SPN, activates the same fusion process of bacteria-containing vesicles (BCVs) with TfR vesicles, which enables those bacteria to exploit TfR transcytosis to penetrate the BBB, and illustrate the details of this process in HBMECs and mouse models.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:06:33.267.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	yang wen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-22 02:24:22	ID requested
1	2023-10-24 10:26:46	announced
⏵ 2	2023-11-14 09:06:41	announced	2023-11-14: Updated project metadata.

Cheng Z, Zheng Y, Yang W, Sun H, Zhou F, Huang C, Zhang S, Song Y, Liang Q, Yang N, Li M, Liu B, Feng L, Wang L, Pathogenic bacteria exploit transferrin receptor transcytosis to penetrate the blood-brain barrier. Proc Natl Acad Sci U S A, 120(39):e2307899120(2023) [pubmed]

submitter keyword: LC-MS, hbmec,human

Wang Lei
contact affiliation	TEDA Institute of Biological Sciences and Biotechnology, Nankai University, China
contact email	wanglei@nankai.edu.cn
lab head
yang wen
contact affiliation	Nankai University
contact email	yangwen@mail.nankai.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD039060

PRIDE project URI

• PRIDE
  1. PXD039060
     1. Label: PRIDE project
     2. Name: Pathogenic Bacteria Exploit Transferrin Receptor Transcytosis to Penetrate the Blood‒Brain Barrier