PXD039033

PXD039033 is an original dataset announced via ProteomeXchange.

Title	Signaling network response to alpha-particle targeted therapy with actinium-225 labeled minigastrin analogue 225Ac-PP-F11N
Description	Alpha-particle emitters have recently been explored as valuable therapeutic radionuclides. Yet, toxicity to healthy organs and cancer radioresistance limit the efficacy of targeted alpha-particle therapy (TAT). Identification of the radiation-activated mechanisms, which drive cancer cell survival, provides opportunities to develop new points for therapeutic interference to improve the efficacy and safety of TAT. Quantitative phosphoproteomics and matching proteomics followed were employed to identify alterations in the signaling networks in response to TAT with actinium-225 labeled minigastrin analogue 225Ac-PP-F11N in A431 cells, which overexpress cholecystokinin B receptor (CCKBR).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:46:17.063.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michal Grzmil
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-21 06:00:23	ID requested
1	2023-06-02 01:38:14	announced
2	2023-11-14 09:00:23	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:46:17	announced	2024-10-22: Updated project metadata.

10.2967/JNUMED.122.264597;

submitter keyword: Human, cancer, proteomics, radioresistance, phosphoproteomics, minigastrin

Michal Grzmil
contact affiliation	Paul Scherrer Institute Center for Radiopharmaceutical Sciences Forschungsstrasse 111 5232 Villigen PSI Switzerland
contact email	michal.grzmil@psi.ch
lab head
Michal Grzmil
contact affiliation	Paul Scherrer Institute Center for Radiopharmaceutical Sciences
contact email	michal.grzmil@psi.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD039033

PRIDE project URI

• PRIDE
  1. PXD039033
     1. Label: PRIDE project
     2. Name: Signaling network response to alpha-particle targeted therapy with actinium-225 labeled minigastrin analogue 225Ac-PP-F11N