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PXD039028

PXD039028 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt
DescriptionWe use HDX-MS to interrogate the AKT1 DrLink conformational changes upon binding AKT1 active site inhibitors A-443654, Capivasertib, and Uprosertib, Akt1 allosteric inhibitor MK-2206, and ADP.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:56:18.681.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJohn Burke
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
Instrumentimpact HD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-21 04:45:32ID requested
12024-08-23 14:36:10announced
22024-10-22 06:56:19announced2024-10-22: Updated project metadata.
Publication List
10.1016/j.str.2023.01.007;
Shaw AL, Parson MAH, Truebestein L, Jenkins ML, Leonard TA, Burke JE, ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1. Structure, 31(3):343-354.e3(2023) [pubmed]
Keyword List
submitter keyword: AKT1 DrLink, ATP competitive inhibitors, allosteric inhibitors,AKT1, Protein Kinase B, HDX-MS
Contact List
Dr. John E Burke
contact affiliationUniversity of Victoria
contact emailjeburke@uvic.ca
lab head
John Burke
contact affiliationUniversity of Victoria
contact emailjeburke@uvic.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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