PXD039028

PXD039028 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt
Description	We use HDX-MS to interrogate the AKT1 DrLink conformational changes upon binding AKT1 active site inhibitors A-443654, Capivasertib, and Uprosertib, Akt1 allosteric inhibitor MK-2206, and ADP.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:56:18.681.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John Burke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	impact HD

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-21 04:45:32	ID requested
1	2024-08-23 14:36:10	announced
⏵ 2	2024-10-22 06:56:19	announced	2024-10-22: Updated project metadata.

Publication List

10.1016/j.str.2023.01.007;
Shaw AL, Parson MAH, Truebestein L, Jenkins ML, Leonard TA, Burke JE, ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1. Structure, 31(3):343-354.e3(2023) [pubmed]

10.1016/j.str.2023.01.007;

Shaw AL, Parson MAH, Truebestein L, Jenkins ML, Leonard TA, Burke JE, ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1. Structure, 31(3):343-354.e3(2023) [pubmed]

Keyword List

submitter keyword: AKT1 DrLink, ATP competitive inhibitors, allosteric inhibitors,AKT1, Protein Kinase B, HDX-MS

submitter keyword: AKT1 DrLink, ATP competitive inhibitors, allosteric inhibitors,AKT1, Protein Kinase B, HDX-MS

Contact List

Dr. John E Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
lab head
John Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD039028
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD039028

PRIDE project URI

Repository Record List

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